30450
柔红霉素 盐酸盐
≥90% (HPLC)
别名:
道诺霉素 盐酸盐
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关于此项目
经验公式（希尔记法）:
C27H29NO10 · HCl
化学文摘社编号:
分子量:
563.98
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
245-723-4
Beilstein/REAXYS Number:
4229221
MDL number:
biological source
synthetic
Quality Segment
assay
≥90% (HPLC)
form
powder
color
red to deep red
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InChI
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
Gene Information
human ... TOP2A(7153)
General description
Chemical structure: aminoglycoside
Application
Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.
Biochem/physiol Actions
强效抗癌药。抑制 DNA 和 RNA 合成，作为序列特异性 ds-DNA 嵌入剂。
On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Packaging
5 mg, 25 mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges