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Merck
CN

30960

脱氧胆酸

≥99.0% (T)

别名:

3α,12α-二羟基-5β-胆甾烯酸, 7-脱氧胆酸, 脱氧胆酸

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关于此项目

经验公式（希尔记法）:
C24H40O4
化学文摘社编号:
83-44-3
分子量:
392.57
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
329753610
EC Number:
201-478-5
Beilstein/REAXYS Number:
3219882
MDL number:
MFCD00003673

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产品名称

脱氧胆酸, ≥99.0% (T)

InChI key

KXGVEGMKQFWNSR-LLQZFEROSA-N

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

biological source

ox bile

description

anionic

assay

≥99.0% (T)

form

powder

optical activity

[α]20/D +54±1°, c = 1% in ethanol

mol wt

392.57 g/mol

impurities

≤1% cholic acid (TLC)

mp

170-175 °C
171-174 °C (lit.)

functional group

carboxylic acid

Quality Level

100

Gene Information

human ... ATIC(471)

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相关类别

Application

使用脱氧胆酸用作：
  • 体外测定中的菌丝抑制化合物，以研究胃肠道中白色念珠菌的菌丝形态发生
  • 一种用于估计细胞团块中毒素浓度的内部标准品
  • 采用超高效液相色谱三重四极杆质谱联用技术定量在接受治疗的小鼠各种样品中定量测定BA的胆汁酸(BA)颗粒

Biochem/physiol Actions

脱氧胆酸的两亲性特性可显著有助于溶解、乳化和吸收体内的脂肪、维生素和胆固醇等。肠内脱氧胆酸含量高可通过诱导氧化应激和DNA损伤导致结肠直肠癌。它是一种致癌和促肿瘤因子。

General description

脱氧胆酸是一种两亲分子，是胆汁酸的重要组成部分。它包括3α和12α位取代的羟基和支链末端的羧基。这些组成成分可对分子的亲水性产生影响并且疏水环戊烯并菲形成其中心。

Other Notes

用于β-肾上腺素能受体的增溶

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM5518
BCCL7459
BCCL0189
BCCH8920
BCCG6672

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