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Merck
CN

30960

Sigma-Aldrich

脱氧胆酸

≥99.0% (T)

别名:

3α,12α-二羟基-5β-胆甾烯酸, 7-脱氧胆酸, 脱氧胆酸

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关于此项目

经验公式（希尔记法）:
C24H40O4
CAS Number:
83-44-3
分子量:
392.57
Beilstein:
3219882
EC 号:
201-478-5
MDL编号:
MFCD00003673
UNSPSC代码:
12352106
PubChem化学物质编号:
329753610
NACRES:
NA.77

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生物来源

ox bile

质量水平

100

描述

anionic

方案

≥99.0% (T)

表单

powder

旋光性

[α]20/D +54±1°, c = 1% in ethanol

分子量

392.57 g/mol

杂质

≤1% cholic acid (TLC)

mp

170-175 °C
171-174 °C (lit.)

官能团

carboxylic acid

SMILES字符串

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

InChI key

KXGVEGMKQFWNSR-LLQZFEROSA-N

基因信息

human ... ATIC(471)

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相关类别

一般描述

脱氧胆酸是一种两亲分子，是胆汁酸的重要组成部分。它包括3α和12α位取代的羟基和支链末端的羧基。这些组成成分可对分子的亲水性产生影响并且疏水环戊烯并菲形成其中心。

应用

使用脱氧胆酸用作：
  • 体外测定中的菌丝抑制化合物，以研究胃肠道中白色念珠菌的菌丝形态发生
  • 一种用于估计细胞团块中毒素浓度的内部标准品
  • 采用超高效液相色谱三重四极杆质谱联用技术定量在接受治疗的小鼠各种样品中定量测定BA的胆汁酸(BA)颗粒

生化/生理作用

脱氧胆酸的两亲性特性可显著有助于溶解、乳化和吸收体内的脂肪、维生素和胆固醇等。肠内脱氧胆酸含量高可通过诱导氧化应激和DNA损伤导致结肠直肠癌。它是一种致癌和促肿瘤因子。

其他说明

用于β-肾上腺素能受体的增溶

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM5518
BCCL7459
BCCL0189
BCCH8920
BCCG6672

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