311R-1
PAX-2 (EP235) Rabbit Monoclonal Primary Antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP235, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
Species reactivity:
human
Citations:
3
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
EP235, monoclonal
description
(For In Vitro Diagnostic Use in Select Regions (See Chart))
form
buffered aqueous solution
species reactivity
human
packaging
bottle of 1.0 mL predilute (311R-17)
bottle of 7.0 mL predilute (311R-18)
vial of 0.1 mL concentrate (311R-14)
vial of 0.5 mL concentrate (311R-15)
vial of 1.0 mL concentrate (311R-16)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
isotype
IgG
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... PAX2(5076)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1 Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2 More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).3
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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J R Gnarra et al.
Cancer research, 55(18), 4092-4098 (1995-09-15)
Renal cell carcinoma (RCC) is the most common malignancy in the adult kidney. Because RCC is generally thought to arise from the epithelium of the proximal tubules, the expression of Pax-2, a gene required for renal epithelium development, was examined
Mamatha Chivukula et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 28(6), 570-578 (2009-10-24)
Ovarian serous papillary carcinoma, although rarely metastasizing to the breast, is often challenging based on morphology alone, particularly from the micropapillary variant of breast carcinoma. Gross cystic disease fluid protein-15, although a specific marker, can be negative in up to
Peter R Mazal et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(4), 535-540 (2004-10-27)
Diagnostic use of antibodies against aquaporin water channel proteins and PAX-2, a nuclear transcription factor in renal development, was tested in 202 renal neoplasms, using tissue microarray technique. Immunohistochemistry for aquaporin-1, aquaporin-2, PAX-2, CD10, and cytokeratin 7 was performed on
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