biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
SP53, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (314R-14)
vial of 0.5 mL concentrate (314R-15)
bottle of 1.0 mL predilute (314R-17)
vial of 1.0 mL concentrate (314R-16)
bottle of 7.0 mL predilute (314R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG
control
squamous carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... KRT14(3861)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Cytokeratin 14 is a 50 kDa polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is expressed in most squamous cell carcinomas, in epithelioid mesothelioma, and in the basal-like phenotype of breast carcinoma.
Anti-CK14 has been demonstrated to be useful in differentiating squamous cell carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from its renal mimics, as well as in identifying metaplastic carcinomas of the breast. Anti-CK14 is particularly valuable in identifying basal-like carcinoma of the breast.
Anti-CK14 has been demonstrated to be useful in differentiating squamous cell carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from its renal mimics, as well as in identifying metaplastic carcinomas of the breast. Anti-CK14 is particularly valuable in identifying basal-like carcinoma of the breast.
Other Notes
Cytokeratin 14 Positive Control Slides, Product No. 314S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 166-176 (2002)
P G Chu et al.
Histopathology, 39(1), 9-16 (2001-07-17)
The tissue distribution of cytokeratin 14 (CK14) in epithelial neoplasms is not well defined. We have evaluated 435 cases of epithelial neoplasm of various origins with cytokeratin 14 monoclonal antibody with special attention to possible use in differential diagnosis. Immunohistochemistry
Jorge S Reis-Filho et al.
Applied immunohistochemistry & molecular morphology : AIMM, 11(1), 1-8 (2003-03-01)
Metaplastic carcinomas of the breast (MCBs) are unusual neoplasms characterized by an admixture of glandular epithelial components, which frequently exhibit features of squamous differentiation, and mesenchymal malignant components. Regardless of the presence of myoepithelial features in MCB, no consensus concerning
P G Chu et al.
Histopathology, 39(5), 455-462 (2001-12-12)
The cytokeratin 14 (CK14) expression in oncocytomas or oncocytic tumours of various tissue origins has not been established. We have studied CK14 expression in 30 cases of oncocytic tumours of various tissue origins and 33 cases of renal cell carcinoma
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