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Merck
CN

315R-1

PD-1 (EP239) Rabbit Monoclonal Primary Antibody

别名:

CD279, PD1, PDCD1, SLEB2, hPH-1, hSLE1, programmed cell death 1, programmed cell death protein 1, protein PD-1, systemic lupus erythematosus suseptibilitl 2

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP239, monoclonal
Application:
IHC (p)
Citations:
8

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP239, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (315R-14), vial of 0.1 mL concentrate Research Use Only (315R-14-RUO), vial of 0.5 mL concentrate (315R-15), vial of 1.0 mL concentrate (315R-16), vial of 1.0 mL concentrate Research Use Only (315R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (315R-17-RUO), vial of 1.0 mL predilute ready-to-use (315R-17), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (315R-18-RUO), vial of 7.0 mL predilute ready-to-use (315R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

lymph node, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Quality Level

100, 500

Gene Information

human ... PDCD1(5133)

相关类别

General description

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

Physical form

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Analysis Note

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000459521
0000459521
0000451591
0000452126
0000451591

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Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome.
Kobayashi M, Kawano S, Hatachi S, et al.
The Journal of Rheumatology, 32(11), 2156-2163 (2005)
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Hamanishi J, Mandai M, Iwasaki M, et al.
Proceedings of the National Academy of Sciences of the USA, 104(9), 3360-3365 (2007)
David M Dorfman et al.
The American journal of surgical pathology, 30(7), 802-810 (2006-07-05)
Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of angioimmunoblastic
Yoshiko Iwai et al.
Immunology letters, 83(3), 215-220 (2002-07-04)
PD-1 is an immunoinhibitory receptor, which belongs structurally to the CD28 family. PD-1-deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells. However
Anne Isine Bolstad et al.
Arthritis and rheumatism, 48(1), 174-185 (2003-01-16)
To assess salivary gland tissues obtained from patients with primary Sjögren's syndrome (SS) for the gene expression profile of the candidate genes TNFRSF6 (Fas), TNFSF6 (FasL), SSA1 (Ro52 alpha and the splice variant Ro52 beta), SSB (La), CTLA4, PDCD1 (PD-1)
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