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321R-2

PLAP (EP194) Rabbit Monoclonal Primary Antibody

Name: PLAP (EP194) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

别名:

Placental Alkaline Phosphatase

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关于此项目

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP194, monoclonal

Application:

IHC (p)

Citations:

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属性

biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP194, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (321R-24), vial of 0.1 mL concentrate Research Use Only (321R-24-RUO), vial of 0.5 mL concentrate (321R-25), vial of 1.0 mL concentrate (321R-26), vial of 1.0 mL concentrate Research Use Only (321R-26-RUO), vial of 1.0 mL pre-dilute Research Use Only (321R-27-RUO), vial of 1.0 mL pre-dilute ready-to-use (321R-27), vial of 7.0 mL pre-dilute ready-to-use (321R-28), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (321R-28-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

placenta

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... ALPP(250)

说明

General description

Placental alkaline phosphatase (PLAP) is normally produced by primordial germ cells and syncytiotrophoblasts, and the detection of its expression has been useful in identifying germ cell tumors.Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. Complete hydatidiform mole shows strong expression of hCG and weak expression of PLAP. Weak hCG and strong PLAP expression is found in partial hydatidiform mole. Choriocarcinoma presents strong expression of hCG and weak expression of hPL and PLAP.8 In addition to its role as a germ cell marker, PLAP may also be used as a myogenic marker in identifying soft tissue tumors.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

PLAP Positive Control Slides, Product No. 321S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c