biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
D2-40, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (322M-14)
vial of 0.5 mL concentrate (322M-15)
bottle of 1.0 mL predilute (322M-17)
vial of 1.0 mL concentrate (322M-16)
bottle of 7.0 mL predilute (322M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:20-1:100
isotype
IgG1
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... PDPN(10630)
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Podoplanin Positive Control Slides, Product No. 322S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
General description
Podoplanin is a transmembrane mucoprotein (38 kD) recognized by the D2-40 monoclonal antibody. Podoplanin is selectively expressed in normal and malignant lymphatic endothelium, including Kaposi’s sarcomas. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas and seminomas.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Csaba Galambos et al.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 8(2), 181-189 (2005-02-19)
The distinction between lymphatic and other vascular vessels on microscopic sections is a challenging task. D2-40, a novel antibody, has been reported to be selective for lymphatic endothelium. We studied the specificity and sensitivity of D2-40 in pediatric vascular tumors
Nelson G Ordóñez
Human pathology, 36(4), 372-380 (2005-05-14)
Recent investigations have shown that podoplanin and the D2-40 monoclonal antibody, which reacts with an oncofetal antigen present in fetal germ cells, are highly reliable lymphatic endothelial markers. The observation that both of these markers are also expressed in normal
Folker E Franke et al.
Journal of cutaneous pathology, 31(5), 362-367 (2004-04-03)
Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a small benign vascular tumor of the superficial and mid-dermis. In contrast to its well-characterized histology, it has been unclear whether this tumor arises from blood vessel endothelial cells (BECs) or lymphatic vessel endothelial
Alexandra N Kalof et al.
Advances in anatomic pathology, 16(1), 62-64 (2008-12-23)
D2-40 is a commercially available monoclonal antibody directed against human podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelial cells. Since its introduction, D2-40 immunoexpression has been described in a variety of lymphovascular neoplasms including lymphangioma, Kaposi sarcoma, and
Nelson G Ordóñez
Advances in anatomic pathology, 13(2), 83-88 (2006-05-04)
Podoplanin is a transmembrane mucoprotein recognized by the recently commercially available D2-40 monoclonal antibody. Recent investigations have shown that podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable
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