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Merck
CN

34025

Sigma-Aldrich

双溴二胺

BioReagent, suitable for fluorescence, ≥95.0% (CHN)

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About This Item

经验公式(希尔记法):
C10H10Br2N2O2
CAS号:
分子量:
350.01
Beilstein:
4189453
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.32

产品线

BioReagent

质量水平

检测方案

≥95.0% (CHN)

mp

170-172 °C (lit.)

溶解性

DMF: soluble
acetonitrile: soluble
chloroform: soluble

荧光

λex 391 nm in methanol
λex 393 nm; λem 477 nm in 0.1 M Tris pH 7.0, gutathione red

适用性

suitable for fluorescence

储存温度

2-8°C

SMILES字符串

CC1=C(CBr)N2N(C1=O)C(=O)C(C)=C2CBr

InChI

1S/C10H10Br2N2O2/c1-5-7(3-11)13-8(4-12)6(2)10(16)14(13)9(5)15/h3-4H2,1-2H3

InChI key

OSIYFMVMZXJKSP-UHFFFAOYSA-N

应用

Dibromobimane是一种双官能化硫醇试剂,用作半胱氨酸谱图和研究蛋白质结构/构象及交联过程的交联剂。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

荧光硫醇特异性标记试剂

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Hai Po Helena Liang et al.
The Biochemical journal, 437(3), 455-460 (2011-05-21)
TF (tissue factor) is a transmembrane cofactor that initiates blood coagulation in mammals by binding Factor VIIa to activate Factors X and IX. The cofactor can reside in a cryptic configuration on primary cells and de-encryption may involve a redox
Zhenhui Chen et al.
The Journal of biological chemistry, 281(20), 14163-14172 (2006-03-24)
Interactions between the transmembrane domains of phospholamban (PLB) and the cardiac Ca2+ pump (SERCA2a) have been investigated by chemical cross-linking. Specifically, C-terminal, transmembrane residues 45-52 of PLB were individually mutated to Cys, then cross-linked to V89C in the M2 helix
E Kim et al.
Journal of molecular biology, 299(2), 421-429 (2000-06-22)
The DNase I binding loop (residues 38-52), the hydrophobic plug (residues 262-274), and the C terminus region are among the structural elements of monomeric (G-) actin proposed to form the intermonomer interface in F-actin. To test the proximity and interactions
T W Loo et al.
The Journal of biological chemistry, 275(50), 39272-39278 (2000-10-03)
P-glycoprotein (P-gp) can transport a wide variety of cytotoxic compounds that have diverse structures. Therefore, the drug-binding domain of the human multidrug resistance P-gp likely consists of residues from multiple transmembrane (TM) segments. In this study, we completed cysteine-scanning mutagenesis
Francisco J Sánchez-Gómez et al.
Molecular pharmacology, 78(4), 723-733 (2010-07-16)
Glutathione transferase P1-1 (GSTP1-1) plays crucial roles in cancer chemoprevention and chemoresistance and is a key target for anticancer drug development. Oxidative stress or inhibitor-induced GSTP1-1 oligomerization leads to the activation of stress cascades and apoptosis in various tumor cells.

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