34025
双溴二胺
BioReagent, suitable for fluorescence, ≥95.0% (CHN)
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关于此项目
经验公式（希尔记法）:
C10H10Br2N2O2
化学文摘社编号:
分子量:
350.01
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4189453
产品名称
双溴二胺, BioReagent, suitable for fluorescence, ≥95.0% (CHN)
InChI
1S/C10H10Br2N2O2/c1-5-7(3-11)13-8(4-12)6(2)10(16)14(13)9(5)15/h3-4H2,1-2H3
SMILES string
CC1=C(CBr)N2N(C1=O)C(=O)C(C)=C2CBr
InChI key
OSIYFMVMZXJKSP-UHFFFAOYSA-N
product line
BioReagent
assay
≥95.0% (CHN)
mp
170-172 °C (lit.)
solubility
DMF: soluble
acetonitrile: soluble
chloroform: soluble
fluorescence
λex 391 nm in methanol
λex 393 nm; λem 477 nm in 0.1 M Tris pH 7.0, gutathione red
suitability
suitable for fluorescence
storage temp.
2-8°C
Quality Level
Application
Dibromobimane是一种双官能化硫醇试剂，用作半胱氨酸谱图和研究蛋白质结构/构象及交联过程的交联剂。
Other Notes
荧光硫醇特异性标记试剂
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hai Po Helena Liang et al.
The Biochemical journal, 437(3), 455-460 (2011-05-21)
TF (tissue factor) is a transmembrane cofactor that initiates blood coagulation in mammals by binding Factor VIIa to activate Factors X and IX. The cofactor can reside in a cryptic configuration on primary cells and de-encryption may involve a redox
Zhenhui Chen et al.
The Journal of biological chemistry, 281(20), 14163-14172 (2006-03-24)
Interactions between the transmembrane domains of phospholamban (PLB) and the cardiac Ca2+ pump (SERCA2a) have been investigated by chemical cross-linking. Specifically, C-terminal, transmembrane residues 45-52 of PLB were individually mutated to Cys, then cross-linked to V89C in the M2 helix
E Kim et al.
Journal of molecular biology, 299(2), 421-429 (2000-06-22)
The DNase I binding loop (residues 38-52), the hydrophobic plug (residues 262-274), and the C terminus region are among the structural elements of monomeric (G-) actin proposed to form the intermonomer interface in F-actin. To test the proximity and interactions
Wiebke Albrecht et al.
Archives of toxicology, 93(6), 1609-1637 (2019-06-30)
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation
D Mornet et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(6), 1658-1662 (1985-03-01)
A bifunctional fluorescent alkylating agent, dibromobimane, has been used to stabilize a preexisting primary loop in myosin subfragment 1 (S-1). The crosslink achieved joins Cys-707 (called sulfhydryl group "SH1") of the 20-kDa domain (formerly called "20K" domain) with a thiol
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