biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
T311, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (344M-94), vial of 0.5 mL concentrate (344M-95), bottle of 1.0 mL predilute (344M-97), vial of 1.0 mL concentrate (344M-96), bottle of 7.0 mL predilute (344M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG2a
control
melanoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... TYR(7299)
General description
Tyrosinase is an enzyme, amongst a family of enzymes, which is involved in the biosynthesis of melanin. Anti-tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma and melanotic neurofibroma. Essentially no carcinomas express this marker.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Tyrosinase Positive Control Slides, Product No. 344S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
Nele Jaanson et al.
Melanoma research, 13(5), 473-482 (2003-09-27)
Tyrosinase, the critical enzyme in melanin synthesis, is also found to be expressed in most malignant melanomas and can serve as a target for the immune response by both CD4+ and CD8+ T-cells. Therefore it could be used as a
K J Busam et al.
The American Journal of dermatopathology, 22(3), 237-241 (2000-06-28)
Histiocytic tumors can be confused with melanocytic nevi and malignant melanoma and vice versa. To explore the use of immunohistochemistry for this diagnostic problem, we examined the expression of S-100 protein, gp100 (the antigen recognized by HMB-45), tyrosinase (T311), Melan-A
C B Meije et al.
The Journal of pathology, 190(5), 572-578 (2000-03-23)
The in situ expression of antigens associated with melanosomes (gp-100), pigmentation (PAA), tyrosinase (TRP-1), melanoma (MAA-1/MAA-2), and HLA-DR was investigated immunohistochemically in frozen archival specimens of common acquired melanocytic naevi, in dysplastic melanocytic naevi, and in lymph node metastases of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 344M-96 | 0841683137436 |
| 344M-97 | 0841683137443 |
| 344M-95 | 0841683137429 |
| 344M-98 | 0841683137450 |
| 344M-94 | 0841683137412 |