Merck
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安全信息

352R-1

Sigma-Aldrich

Napsin A (EP205) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP205, monoclonal

描述

(For In Vitro Diagnostic Use in Select Regions (See Chart))

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (352R-14)
vial of 0.5 mL concentrate (352R-15)
bottle of 1.0 mL predilute (352R-17)
vial of 1.0 mL concentrate (352R-16)
bottle of 7.0 mL predilute (352R-18)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同位素/亚型

IgG

控制

lung adenocarcinoma, renal cell carcinoma

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

基因信息

human ... NAPSA(9476)

相关类别

一般描述

Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.1-5

质量


IVD
IVD
IVD
RUO

联系

Napsin A Positive Control Slides, Product No. 352S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

法规信息

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Jaishree Jagirdar
Archives of pathology & laboratory medicine, 132(3), 384-396 (2008-03-06)
Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from
Jiqing Ye et al.
Applied immunohistochemistry & molecular morphology : AIMM, 19(4), 313-317 (2011-04-06)
Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging, and it demands sensitive and specific biomarkers, especially when the tissue for diagnosis is limited. Thyroid transcription factor-1 (TTF-1) has been considered a reliable marker for adenocarcinoma of
Annika Dejmek et al.
Diagnostic cytopathology, 35(8), 493-497 (2007-07-20)
The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on formalin-fixed paraffin embedded
Kentaro Inamura et al.
The American journal of surgical pathology, 29(5), 660-665 (2005-04-16)
Primary pulmonary adenocarcinomas with enteric differentiation (PAED) are mainly composed of tall-columnar cells that show similarity to intestinal epithelia and colorectal carcinomas. In this study, we analyzed the immunostaining profiles of 7 PAEDs in comparison with 14 metastatic colorectal carcinomas
Justin A Bishop et al.
Human pathology, 41(1), 20-25 (2009-09-11)
Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung

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