biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
6E3, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (385M-14)
vial of 0.5 mL concentrate (385M-15)
bottle of 1.0 mL predilute (385M-17)
vial of 1.0 mL concentrate (385M-16)
bottle of 7.0 mL predilute (385M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1
control
dysgerminoma, seminoma
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... SALL4(57167)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Sal-like protein 4 (SALL4) is a zinc-finger transcription factor that serves as a master regulator of embryonic pluripotency and is involved in processes associated with stem cell activities. SALL4 expression in germ cells makes it a useful marker for germ cell tumors such as seminoma, embryonal carcinoma, yolk sac tumors, and teratomas. SALL4 expression is also seen in the spermatogonia of the normal testis.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
SALL4 Positive Control Slides, Product No. 385S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Wei Cui et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(12), 1585-1592 (2006-09-26)
SALL4, a newly identified zinc-finger transcriptional factor important for embryonic development, is mapped to chromosome 20q13. Previously, we reported that SALL4 was constitutively expressed in acute myeloid leukemia and SALL4 transgenic mice developed acute myeloid leukemia. In this study, we
Dengfeng Cao et al.
The American journal of surgical pathology, 33(6), 894-904 (2009-03-20)
Ovarian primitive germ cell tumors (GCTs) are uncommon tumors and sometimes pose diagnostic challenges. Among them, yolk sac tumor (YST) poses the greatest diagnostic difficulty and can be mistaken for clear cell carcinoma (CCC). Current immunohistochemical markers such as alpha-fetoprotein
Dengfeng Cao et al.
The American journal of surgical pathology, 33(7), 1065-1077 (2009-04-25)
The diagnosis of testicular germ cell tumors (GCTs) sometimes can be challenging without ancillary markers. Here we performed an immunohistochemical study of a novel stem cell marker SALL4 in a large series of 110 primary testicular GCTs (65 pure and
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