Merck
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文件

安全信息

395R-1

Sigma-Aldrich

c-Myc (EP121) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP121, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (395R-14)
vial of 0.5 mL concentrate (395R-15)
bottle of 1.0 mL predilute (395R-17)
vial of 1.0 mL concentrate (395R-16)
bottle of 7.0 mL predilute (395R-18)

制造商/商品名称

Cell Marque

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

同位素/亚型

IgG

控制

Burkitt lymphoma, prostate carcinoma

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... MYC(4609)

一般描述

c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc isamplified in many different solid and hematopoietic tumors. Immunohistochemistry forc-Myc protein is used to identify the presence of a c-Myc translocation in various tumors,most frequently to aid in the diagnosis of Burkitt lymphoma.

质量


IVD

IVD

IVD

RUO

联系

c-Myc Positive Control Slides, Product No. 395S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

法规信息

监管及禁止进口产品

分析证书(COA)

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Rakesh Naidu et al.
International journal of molecular medicine, 9(2), 189-196 (2002-01-12)
Overexpression of c-myc protein and amplification of c-myc were investigated by immunohistochemistry and differential polymerase chain reaction (dPCR) in 440 formalin-fixed primary breast carcinoma tissues, respectively. Overexpression of c-myc was detected in 45% (199/440) and amplification of c-myc was observed
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
C V Dang
Molecular and cellular biology, 19(1), 1-11 (1998-12-22)
Bora Gurel et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(9), 1156-1167 (2008-06-24)
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function and stem cell renewal. A region on chromosome 8q24 encompassing the MYC locus is amplified in prostate cancer, but this occurs mostly in advanced
Tina Marie Green et al.
The American journal of surgical pathology, 36(4), 612-619 (2012-02-09)
Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated
Christopher W Toon et al.
PloS one, 9(2), e87456-e87456 (2014-02-08)
MYC over-expression as determined by molecular means has been reported as a favorable prognostic biomarker in colorectal carcinoma (CRC). However MYC expression analysis is not available in the routine clinical setting. We investigated whether immunohistochemistry (IHC) for the myc protein

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