biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
2E11, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (396M-14), vial of 0.5 mL concentrate (396M-15), bottle of 1.0 mL predilute (396M-17), vial of 1.0 mL concentrate (396M-16), bottle of 7.0 mL predilute (396M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
isotype
IgG1
control
chromophobe renal cell carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... PVALB(5816)
General description
Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis. Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells). Parvalbumin is strongly expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) (100%) and oncocytoma (69%), but is essentially negative in other types of RCCs, such as clear cell RCC and papillary RCC. This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Parvalbumin Positive Control Slides, Product No. 396S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Brian P Adley et al.
Analytical and quantitative cytology and histology, 28(4), 228-236 (2006-08-25)
To investigate the diagnostic value of cytokeratin 7 (CK7) and parvalbumin at mRNA and protein levels. CK7 and parvalbumin mRNA expression levels in 23 oncocytomas and 32 chromophobe renal cell carcinomas (RCCs) were examined using gene expression microarrays. Immunohistochemistry was
G Martignoni et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(8), 760-767 (2001-08-16)
Chromophobe renal carcinoma is composed of neoplastic cell showing several features similar to those found in the intercalated cells of the collecting ducts. Because the distal nephron expresses calcium-binding proteins playing a role in calcium homeostasis, we reasoned that these
Pusiol Teresa et al.
Diagnostic cytopathology, 40(1), 56-61 (2011-12-20)
Malignant effusions because of renal-cell carcinoma (RCC) are an unusual event and occur in patients with papillary and clear cell tumors. We have studied a 65-year-old man who underwent right renal tumorectomy, diagnosed as chromophobe RCC (pT1). After 16 months
Andrew N Young et al.
The American journal of surgical pathology, 27(2), 199-205 (2003-01-28)
The common histopathologic subtypes of renal epithelial neoplasms include conventional, or clear cell, renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, and renal oncocytoma. These subtypes differ clinically and pathologically, making accurate classification important. However, this differential diagnosis can be
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