生物来源
mouse
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
2E11, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (396M-14)
vial of 0.5 mL concentrate (396M-15)
bottle of 1.0 mL predilute (396M-17)
vial of 1.0 mL concentrate (396M-16)
bottle of 7.0 mL predilute (396M-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
同位素/亚型
IgG1
控制
chromophobe renal cell carcinoma
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic
基因信息
human ... PVALB(5816)
一般描述
Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis. Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells). Parvalbumin is strongly expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) (100%) and oncocytoma (69%), but is essentially negative in other types of RCCs, such as clear cell RCC and papillary RCC. This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses.
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
分析说明
 IVD |  IVD |  IVD |  RUO |
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Parvalbumin Positive Control Slides, Product No. 396S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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法规信息
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此项目有
Brian P Adley et al.
Analytical and quantitative cytology and histology, 28(4), 228-236 (2006-08-25)
To investigate the diagnostic value of cytokeratin 7 (CK7) and parvalbumin at mRNA and protein levels. CK7 and parvalbumin mRNA expression levels in 23 oncocytomas and 32 chromophobe renal cell carcinomas (RCCs) were examined using gene expression microarrays. Immunohistochemistry was
Pusiol Teresa et al.
Diagnostic cytopathology, 40(1), 56-61 (2011-12-20)
Malignant effusions because of renal-cell carcinoma (RCC) are an unusual event and occur in patients with papillary and clear cell tumors. We have studied a 65-year-old man who underwent right renal tumorectomy, diagnosed as chromophobe RCC (pT1). After 16 months
G Martignoni et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(8), 760-767 (2001-08-16)
Chromophobe renal carcinoma is composed of neoplastic cell showing several features similar to those found in the intercalated cells of the collecting ducts. Because the distal nephron expresses calcium-binding proteins playing a role in calcium homeostasis, we reasoned that these
Andrew N Young et al.
The American journal of surgical pathology, 27(2), 199-205 (2003-01-28)
The common histopathologic subtypes of renal epithelial neoplasms include conventional, or clear cell, renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, and renal oncocytoma. These subtypes differ clinically and pathologically, making accurate classification important. However, this differential diagnosis can be
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