biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
2E11, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (396M-14), vial of 0.5 mL concentrate (396M-15), bottle of 1.0 mL predilute (396M-17), vial of 1.0 mL concentrate (396M-16), bottle of 7.0 mL predilute (396M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
isotype
IgG1
control
chromophobe renal cell carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... PVALB(5816)
General description
Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis. Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells). Parvalbumin is strongly expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) (100%) and oncocytoma (69%), but is essentially negative in other types of RCCs, such as clear cell RCC and papillary RCC. This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Parvalbumin Positive Control Slides, Product No. 396S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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