biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
SP91, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (404R-14), vial of 0.5 mL concentrate (404R-15), bottle of 1.0 mL predilute (404R-17), vial of 1.0 mL concentrate (404R-16), bottle of 7.0 mL predilute (404R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
isotype
IgG
control
lymph node, tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic, membranous
Gene Information
human ... C4B(721)
General description
Acute humoral rejection is mediated by antibodies to the donor endothelium that activates the classical complement pathway. This leads to a number of split products of complement proteins. C4d is a fragment of C4 complement released during activation of the classic complement pathway by the antigen-antibody complex. C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response. C4d can be a useful tool for indicating acute renal allograft rejection.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
C4d Positive Control Slides, Product No. 404S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Liise K Kayler et al.
Transplantation, 85(6), 813-820 (2008-03-25)
Focal PTC C4d staining in acute renal allograft rejection has not been studied extensively. Renal allograft biopsies performed after October 2003, representing the first episode of acute rejection (AR) in recipients with > or = 12 months follow-up postbiopsy, were
Chen Jianghua et al.
Clinical transplantation, 19(6), 785-791 (2005-11-30)
To determine the diagnostic and clinical significance of C4d accumulation in renal allografts followed by acute rejection. A total of 158 graft biopsies performed from December 1997 to December 2002 were classified, according to the Banff-97 criteria, into hyperacute rejection
Christian A Seemayer et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(2), 568-576 (2006-12-14)
Detection of C4d along peritubular capillaries (PTC) in renal allograft biopsies is an independent prognostic marker of poor long-term graft survival. It is typically associated with circulating donor-specific antibodies. Since only little information is available on the best technique to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 404R-14 | 0841683141341 |
| 404R-18 | 0841683141389 |
| 404R-15 | 0841683141358 |
| 404R-16 | 0841683141365 |
| 404R-17 | 0841683141372 |