42385
Kollicoat® MAE 30 DP
46.0-50.6% methacrylic acid basis (calc. on solids content)
别名:
Methacrylic acid copolymer dispersion, Methacrylic acid-ethyl acrylate copolymer (1:1) dispersion 30 %
产品名称
Kollicoat® MAE 30 DP, 46.0-50.6% methacrylic acid basis (calc. on solids content)
SMILES string
O(CC)C(=O)C=C.OC(=O)C(=C)C
InChI
1S/C5H8O2.C4H6O2/c1-3-5(6)7-4-2;1-3(2)4(5)6/h3H,1,4H2,2H3;1H2,2H3,(H,5,6)
InChI key
GDCRSXZBSIRSFR-UHFFFAOYSA-N
concentration
46.0-50.6% (methacrylic acid, calc. on solids content)
impurities
≤1 ppm arsenic (verified on random samples only)
≤1.00% coagulum content /particulate matter
≤10 ppm heavy metals (verified on random samples only)
ign. residue
≤0.1%
evapn. residue (140 °C, 30 min.)
28.5-31.5%
loss
68.5-71.5% loss on drying, 140°C, 30 min.
pH
2.1-3.0
viscosity
≤15 mPa.s(20 °C) (apparent viscosity)
3-15(20 °C) (mm2/s)
density
1.062-1.072
Quality Level
Analysis Note
appearance of a film : clear
Application
Kollicoat polymers can be employed as film coatings (intelligent surfaces) with controlled-release agents, for instant-release or sustained-release applications. Kollicoat polymers can be used with all standard coating equipment and are cost-effective, delivering maximum quality in terms of function, stability, and appearance. This research grade product is intended for use in R&D and development only.
Legal Information
Kollicoat is a registered trademark of BASF SE
Comparative studies with Kollicoat MAE 30 D and Kollicoat MAE 30 DP in aqueous spray dispersions and enteric coatings on highly swellable caffeine cores.
Dangel C, Schepky G, Reich HB, Kolter K.
Drug Devel. Ind. Pharm., 26, 415-421 (2000)
C Guthmann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(2), 667-674 (2008-01-30)
The drug substance SAG/ZK has a short biological half-life and because of its weakly basic nature a strong pH-dependent solubility was observed. The aim of this study was to develop a controlled release (cr) multiple unit pellet formulation for SAG/ZK
A Dashevsky et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 58(1), 45-49 (2004-06-23)
The objective of this study was to obtain pH-independent release profiles from coated pellets containing drugs with pH-dependent solubility. pH-independent release of the basic model drug verapamil HCl was achieved by coating with a combination of the neutral polymer dispersions
H Kranz et al.
International journal of pharmaceutics, 380(1-2), 112-119 (2009-07-28)
The major aim of this study was to identify an efficient tool to adjust drug release patterns from aqueous and organic ethylcellulose (a gastrointestinal insoluble polymer) coated pellets and to evaluate the long term stability of the film coatings. Drug
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