biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
5H6, monoclonal
description
(For In Vitro Diagnostic Use in Select Regions (See Chart))
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (424M-14), vial of 0.5 mL concentrate (424M-15), bottle of 1.0 mL predilute (424M-17), vial of 1.0 mL concentrate (424M-16), bottle of 7.0 mL predilute (424M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG2aκ
control
Wilms’ tumor
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... CITED1(4435)
General description
CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.3 Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.1 CITED1 expression has been shown to persist in blastemal cell populations of human WT.1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.1 CITED1 has been detected in 86.8% of WT Cases.2
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Harold N Lovvorn et al.
Neoplasia (New York, N.Y.), 9(7), 589-600 (2007-08-22)
Wilms' tumors, or nephroblastomas, are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed metanephric mesenchyme within embryonic kidneys. We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators
Scott Boyle et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 236(8), 2321-2330 (2007-07-07)
Early kidney development in mammals is characterized by reciprocal tissue interaction between the ureteric bud and the metanephric mesenchyme. The coordinated response to this interaction is regulated largely at the transcriptional level. Here, we investigate the expression and function of
Andrew J Murphy et al.
Journal of pediatric surgery, 47(6), 1239-1249 (2012-06-19)
SIX2 and CITED1 are transcriptional regulators that specify self-renewing nephronic progenitor cells of the embryonic kidney. We hypothesized that SIX2, which promotes and maintains this stem cell population, and CITED1 remain active in Wilms' tumor (WT). To evaluate expression domains
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