Merck
CN

42597

Supelco

3′-脱氧胸苷 5′-三磷酸 钠盐 溶液

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

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别名:
2′,3′-二脱氧胸苷 5′-三磷酸, ddTTP
经验公式(希尔记法):
C10H16N2NaO13P3
分子量:
488.15
MDL编号:
PubChem化学物质编号:

产品线

BioChemika

等级

puriss. p.a.

检测方案

≥98.0% (HPLC)

浓度

10.0-11.0 mmol/L (UV)

技术

MALDI-MS: suitable

杂质

≤1.5% ddNDP (HPLC)

适用性

corresponds for UV test

储存温度

−20°C

SMILES字符串

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

InChI key

QJSZKDPCBDXBCK-KZYPOYLOSA-M

一般描述

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

包装

packaging : 1 μmol (approx. 91-100 μL)

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Elena N Ilina et al.
Frontiers in microbiology, 4, 186-186 (2013-07-13)
Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.
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Antioxidants (Basel, Switzerland), 10(2) (2021-03-07)
The beneficial effects of moderate red wine consumption on cardiovascular health are well known. The composition of red wine includes several compounds, such as the phytoestrogen resveratrol, that exert these beneficial effects, although not all the mechanisms by which they
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DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology
Kevin A Fiala et al.
Nucleic acids research, 36(6), 1990-2001 (2008-02-16)
Our previous publication shows that Sulfolobus solfataricus Dpo4 utilizes an 'induced-fit' mechanism to select correct incoming nucleotides at 37 degrees C. Here, we provide a comprehensive report elucidating the kinetic mechanism of a DNA polymerase at a reaction temperature higher
Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)

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