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Merck
CN

42597

3′-脱氧胸苷 5′-三磷酸 钠盐 溶液

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

别名:

2′,3′-二脱氧胸苷 5′-三磷酸, ddTTP

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关于此项目

经验公式(希尔记法):
C10H16N2NaO13P3
化学文摘社编号:
分子量:
488.15
UNSPSC Code:
41116105
PubChem Substance ID:
MDL number:
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product line

BioChemika

grade

puriss. p.a.

assay

≥98.0% (HPLC)

concentration

10.0-11.0 mmol/L (UV)

technique(s)

MALDI-MS: suitable

impurities

≤1.5% ddNDP (HPLC)

suitability

corresponds for UV test

storage temp.

−20°C

SMILES string

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

InChI key

QJSZKDPCBDXBCK-KZYPOYLOSA-M

General description

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

Packaging

packaging : 1 μmol (approx. 91-100 μL)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)
Sascha Tierling et al.
Epigenetics & chromatin, 3(1), 12-12 (2010-06-08)
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology
Kevin A Fiala et al.
Nucleic acids research, 36(6), 1990-2001 (2008-02-16)
Our previous publication shows that Sulfolobus solfataricus Dpo4 utilizes an 'induced-fit' mechanism to select correct incoming nucleotides at 37 degrees C. Here, we provide a comprehensive report elucidating the kinetic mechanism of a DNA polymerase at a reaction temperature higher
Sylvia Steininger et al.
Nucleic acids research, 38(6), 1853-1865 (2009-12-31)
The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We
Juan Gambini et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-03-07)
The beneficial effects of moderate red wine consumption on cardiovascular health are well known. The composition of red wine includes several compounds, such as the phytoestrogen resveratrol, that exert these beneficial effects, although not all the mechanisms by which they

全球贸易项目编号

货号GTIN
42597-1UMO-F04061833627129

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