42597
3′-脱氧胸苷 5′-三磷酸 钠盐 溶液
BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)
别名:
2′,3′-二脱氧胸苷 5′-三磷酸, ddTTP
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关于此项目
经验公式（希尔记法）:
C10H16N2NaO13P3
化学文摘社编号:
分子量:
488.15
UNSPSC Code:
41116105
PubChem Substance ID:
MDL number:
InChI
1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1
SMILES string
[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O
InChI key
QJSZKDPCBDXBCK-KZYPOYLOSA-M
product line
BioChemika
grade
puriss. p.a.
assay
≥98.0% (HPLC)
concentration
10.0-11.0 mmol/L (UV)
technique(s)
MALDI-MS: suitable
impurities
≤1.5% ddNDP (HPLC)
suitability
corresponds for UV test
storage temp.
−20°C
General description
3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.
Packaging
packaging : 1 μmol (approx. 91-100 μL)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The beneficial effects of moderate red wine consumption on cardiovascular health are well known. The composition of red wine includes several compounds, such as the phytoestrogen resveratrol, that exert these beneficial effects, although not all the mechanisms by which they
Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)
Sascha Tierling et al.
Epigenetics & chromatin, 3(1), 12-12 (2010-06-08)
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology
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