42597
3′-脱氧胸苷 5′-三磷酸 钠盐 溶液
BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)
别名:
2′,3′-二脱氧胸苷 5′-三磷酸, ddTTP
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关于此项目
经验公式（希尔记法）:
C10H16N2NaO13P3
化学文摘社编号:
分子量:
488.15
MDL编号:
UNSPSC代码:
41116105
PubChem化学物质编号:
产品线
BioChemika
等级
puriss. p.a.
方案
≥98.0% (HPLC)
浓度
10.0-11.0 mmol/L (UV)
技术
MALDI-MS: suitable
杂质
≤1.5% ddNDP (HPLC)
适用性
corresponds for UV test
储存温度
−20°C
SMILES字符串
[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O
InChI
1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1
InChI key
QJSZKDPCBDXBCK-KZYPOYLOSA-M
一般描述
3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.
包装
packaging : 1 μmol (approx. 91-100 μL)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Sascha Tierling et al.
Epigenetics & chromatin, 3(1), 12-12 (2010-06-08)
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology
Kevin A Fiala et al.
Nucleic acids research, 36(6), 1990-2001 (2008-02-16)
Our previous publication shows that Sulfolobus solfataricus Dpo4 utilizes an 'induced-fit' mechanism to select correct incoming nucleotides at 37 degrees C. Here, we provide a comprehensive report elucidating the kinetic mechanism of a DNA polymerase at a reaction temperature higher
Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)
E Matthes et al.
Biochemical and biophysical research communications, 148(1), 78-85 (1987-10-14)
The sugar-modified dTTP analogues 2',3'-didehydro-2',3'-dideoxy-thymidine 5'-triphosphate (ddeTTP), 2',3'-dideoxythymidine 5'-triphosphate (ddTTP), 3'-fluorothymidine 5'-triphosphate (FdTTP), and 3'-azidothymidine 5'-triphosphate (N3dTTP) are demonstrated to be very effective and selective inhibitors of the HIV-associated reverse transcriptase (HIV-RT). This conclusion is based on a comparison of
Jess Tyson et al.
BMC genomics, 10, 453-453 (2009-09-30)
Copy number variation (CNV) in the human genome is recognised as a widespread and important source of human genetic variation. Now the challenge is to screen for these CNVs at high resolution in a reliable, accurate and cost-effective way. Multiplex
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