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Merck
CN

426R-1

STAT6 (EP325) Rabbit Monoclonal Primary Antibody

别名:

Signal Transducer and Activator of Transcription

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP325, monoclonal
Application:
IHC (p)
Citations:
3

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP325, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (426R-14), vial of 0.1 mL concentrate Research Use Only (426R-14-RUO), vial of 0.5 mL concentrate (426R-15), vial of 1.0 mL concentrate (426R-16), vial of 1.0 mL concentrate Research Use Only (426R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (426R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (426R-17), vial of 7.0 mL pre-dilute ready-to-use (426R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (426R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

solitary fibrous tumor

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Quality Level

100, 500

Gene Information

human ... STAT6(6778)

相关类别

General description

STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors. Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays. NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas. This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000493761
0000493763
0000493763
0000493761
0000482695

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Christian Koelsche et al.
Histopathology, 65(5), 613-622 (2014-04-08)
Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study was to verify the utility of STAT6
Alison L Cheah et al.
Pathology, 46(5), 389-395 (2014-07-01)
Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6
Leonille Schweizer et al.
Acta neuropathologica, 125(5), 651-658 (2013-04-12)
Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity now subsumed under the entity SFT. Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided

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