Merck
CN

42966

Sigma-Aldrich

Kolliphor® HS 15

登录查看公司和协议定价

别名:
Solutol® HS 15, 聚乙二醇(15)-羟基硬脂酸酯, 聚氧乙烯化的12-羟基硬脂酸
CAS号:
PubChem化学物质编号:

描述

non-ionic

质量水平

形式

paste

组成

free macrogoly% (27.0 - 39.0 g/100g (%))

杂质

acetic acid (≤ 0.5 g/100g (%))
water (≤ 0.5 g/100g (%))
≤0.05% acetic acid
≤0.05% water
≤1 mg/kg ethylene oxide ((ppm))
≤1 mg/kg ethylene oxide
≤1 mg/kg nickel ((ppm))
≤1 mg/kg nickle
≤10 mg/kg dioxane ((ppm))
≤10 mg/kg dioxane
≤10 mg/kg heavy metals
≤620 mg/kg Diethylene glycol
≤620 mg/kg diethylene glycol ((ppm))
≤620 mg/kg ethylene glycol ((ppm))
≤620 mg/kg ethylene glycol
<10 mg/kg heavy metals ((ppm))

灼烧残渣

(≤ 0.3 g/100g (%))

pH值(酸碱度)

5.0-7.0 (1 g/10 mL in H2O)

mp

25 - 30  °C (77 - 86 °F)

酸值

≤1.0 mg KOH/g

羟基值

90‑110 mg KOH/g

碘值

≤2.0 g I2/100 g

过氧化值

≤3.0 meq/kg

皂化值

53‑63 mg KOH/g

溶解性

water: 200 g/L at 30 °C (86 °F)

密度

1.048 g/cm3 at 20 °C (68 °F)
1.03 g/cm3 at 60 °C (140 °F)

痕量阴离子

<1 ppm (Ethylene Oxide)
<10 ppm (Dioxane)

痕量阳离子

Ni: <1 ppm
heavy metals: <10 ppm

application(s)

sample preservation

SMILES string

C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O

InChI

1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)

InChI key

CYAMZYIUAHNTBO-UHFFFAOYSA-N

一般描述

Kolliphor® HS 15是一种不依赖pH值的非离子表面活性剂,是一种有效的增溶剂和乳化剂。它可溶于水介质和极性有机溶剂,但不溶于非极性溶剂。其结构为12-羟基硬脂酸(亲脂部分)和聚乙二醇(亲水部分)。

应用

Kolliphor® HS 15已用于:
  • 溶解于地塞米松(DEX),以将其腹腔注射到小鼠体内,测试其握力,进而测量肌肉力量
  • 以罗氟司特制剂治疗家兔和豚鼠,以研究臭氧诱导的咳嗽反应的机制和药理敏感性
  • 溶解非奈利酮,以进行口服应用的体内研究

生化/生理作用

Kolliphor® HS 15主要用作肠外和口服制剂中的增溶剂。它是化合物的体外筛选和体内疗效研究的首选。Kolliphor® HS 15还因其增溶特性和安全性,可用于眼科、大分子、栓剂和蛋白质制剂中。通常可形成10-15纳米的胶束。Kolliphor® HS 15可用于开发微乳液IV制剂。

其他说明

Kolliphor HS 15是一种通过使15摩尔环氧乙烷与1摩尔12-羟基硬脂酸反应得到的非离子型去污剂。
For additional information on our range of Biochemicals, please complete this form.

法律信息

Kolliphor is a registered trademark of BASF
Solutol is a registered trademark of BASF SE

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

521.6 °F

闪点(°C)

272 °C


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

为方便起见,与您过往购买产品相关的文件已保存在文档库中。

访问文档库

难以找到您所需的产品或批次号码?

在网站页面上,产品编号会附带包装尺寸/数量一起显示(例如:T1503-25G)。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题?欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ (Lot或Batch)字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等,请输入去除前两位字母的批号:09019TO。

  • 如果您查询到的批号含有填充代码(例如05427ES-021),请输入去除填充代码-021的批号:05427ES。

  • 如果您查询到的批号含有填充代码(例如 STBB0728K9),请输入去除填充代码K9的批号:STBB0728。

未找到您寻找的产品?

部分情况下,可能未在线提供COA。如果搜索不到COA,可在线索取。

索取COA

Li Gan et al.
International journal of pharmaceutics, 365(1-2), 143-149 (2008-09-09)
The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded microemulsion was prepared using castor oil, Solutol HS 15 (surfactant), glycerol
J S Coon et al.
Cancer research, 51(3), 897-902 (1991-02-01)
A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but
Emlyn Clay et al.
The Journal of pharmacology and experimental therapeutics, 357(1), 73-83 (2016-02-04)
Cough remains a major unmet clinical need, and preclinical animal models are not predictive for new antitussive agents. We have investigated the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses in rabbits and guinea pigs. Ozone induced a significant increase
Chengwen Mao et al.
AAPS PharmSciTech, 10(3), 1058-1064 (2009-08-12)
In this study, a nanoemulsion (NE) system was investigated for intravenous delivery of lipophilic and venous irritant drugs. NEs were prepared to deliver diallyl trisulfide (DT) for systemic therapy of bacterial and fungal infection, egg phospholipid was chosen as the
Arnaud Vonarbourg et al.
Biomaterials, 30(18), 3197-3204 (2009-03-31)
Most of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulation leads

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门