biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
EP206, monoclonal
description
(For In Vitro Diagnostic Use in Select Regions (See Chart))
form
buffered aqueous solution
species reactivity
human
packaging
bottle of 1.0 mL predilute (437R-17)
bottle of 7.0 mL predilute (437R-18)
vial of 0.1 mL concentrate (437R-14)
vial of 0.5 mL concentrate (437R-15)
vial of 1.0 mL concentrate (437R-16)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... ITGAE(3682)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
CD103 is an integrin subunit, αE, encoded by the ITGAE gene on chromosome 17.2 CD103 is expressed in almost all cases of hairy cell leukemia (HCL) and absent in the majority of other B-cell neoplasms with an exception to splenic marginal zone lymphoma, in which rare cases express CD103.1,2 CD103 has been found in mononuclear cells in the interfollicular area of lymph nodes and in intraepithelial cells in the overlying mucosa located primarily toward the basal layer of the tonsil.2 The high sensitivity of anti-CD103 for hairy cell leukemia makes this marker valuable when distinguishing from other B-cell neoplasms.
Other Notes
CD103 Positive Control Slides, Product No. 437S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Elizabeth A Morgan et al.
American journal of clinical pathology, 139(2), 220-230 (2013-01-29)
Detection of the integrin subunit CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia (HCL). Currently, flow cytometric analysis (FC) and frozen section immunohistochemistry (IHC) represent the only available methods of detection. This study is the
Henry Y Dong et al.
American journal of clinical pathology, 131(4), 586-595 (2009-03-18)
CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal
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