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安全信息

437R-1

Sigma-Aldrich

CD103 (EP206) Rabbit Monoclonal Primary Antibody

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生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

antibody product type

primary antibodies

克隆

EP206, monoclonal

描述

(For In Vitro Diagnostic Use in Select Regions (See Chart))

形式

buffered aqueous solution

species reactivity

human

包装

bottle of 1.0 mL predilute (437R-17)
bottle of 7.0 mL predilute (437R-18)
vial of 0.1 mL concentrate (437R-14)
vial of 0.5 mL concentrate (437R-15)
vial of 1.0 mL concentrate (437R-16)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

同位素/亚型

IgG

运输

wet ice

储存温度

2-8°C

Gene Information

human ... ITGAE(3682)

一般描述

CD103 is an integrin subunit, αE, encoded by the ITGAE gene on chromosome 17.2 CD103 is expressed in almost all cases of hairy cell leukemia (HCL) and absent in the majority of other B-cell neoplasms with an exception to splenic marginal zone lymphoma, in which rare cases express CD103.1,2 CD103 has been found in mononuclear cells in the interfollicular area of lymph nodes and in intraepithelial cells in the overlying mucosa located primarily toward the basal layer of the tonsil.2 The high sensitivity of anti-CD103 for hairy cell leukemia makes this marker valuable when distinguishing from other B-cell neoplasms.

质量


IVD

IVD

IVD

RUO

联系

CD103 Positive Control Slides, Product No. 437S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

法规信息

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T1503
货号
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包装规格/数量

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Elizabeth A Morgan et al.
American journal of clinical pathology, 139(2), 220-230 (2013-01-29)
Detection of the integrin subunit CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia (HCL). Currently, flow cytometric analysis (FC) and frozen section immunohistochemistry (IHC) represent the only available methods of detection. This study is the
Henry Y Dong et al.
American journal of clinical pathology, 131(4), 586-595 (2009-03-18)
CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal

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