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Merck
CN

442R-1

Sigma-Aldrich

LEF1 (EP310) Rabbit Monoclonal Primary Antibody

别名:

Lymphoid Enhancing Factor 1

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UNSPSC代码:
12352203

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生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP310, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (442R-14)
vial of 0.1 mL concentrate Research Use Only (442R-14-RUO)
vial of 0.5 mL concentrate (442R-15)
vial of 1.0 mL concentrate (442R-16)
vial of 1.0 mL concentrate Research Use Only (442R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (442R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (442R-17)
vial of 7.0 mL pre-dilute ready-to-use (442R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (442R-18-RUO)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

small lymphocytic lymphoma, tonsil

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... LEF1(51176)

相关类别

一般描述

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family. LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells. Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas. Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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分析说明


IVD
IVD
IVD
RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000414925
0000409056
0000409056
0000409053
0000409053

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Kata Boras-Granic et al.
Developmental biology, 295(1), 219-231 (2006-05-09)
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appendages such as hair follicles and mammary glands. Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis. In order to define the role
Rajesh Kumar Gandhirajan et al.
Neoplasia (New York, N.Y.), 12(4), 326-335 (2010-04-03)
Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-1 might lead to killing of
Bevan Tandon et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(11), 1433-1443 (2011-06-21)
Lymphoid-enhancer-binding factor 1 (LEF1), coupling with β-catenin, functions as a key nuclear mediator of WNT/β-catenin signaling, which regulates cell proliferation and survival. LEF1 has an important role in lymphopoiesis, and is normally expressed in T and pro-B cells but not

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