生物来源
mouse
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
Kp10, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (457M-94)
vial of 0.5 mL concentrate (457M-95)
bottle of 1.0 mL predilute (457M-97)
vial of 1.0 mL concentrate (457M-96)
bottle of 7.0 mL predilute (457M-98)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同位素/亚型
IgG2bκ
控制
placenta
运输
wet ice
储存温度
2-8°C
可视化
nuclear
基因信息
human ... CDKN1C(1028)
一般描述
Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In normal placenta, cytotrophoblast, syncytio trophoblast, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
p57 is a human tumor suppressor gene encoded on the 11p15.5 chromosomal sequence. Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In the normal placenta, cytotrophoblast, intermediate trophoblast and decidual cells, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
分析说明
 IVD |  IVD |  IVD |  RUO |
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
P57Kip2 Positive Control Slides, Product No. 457S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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法规信息
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此项目有
Maki Kihara et al.
The Journal of reproductive medicine, 50(5), 307-312 (2005-06-24)
To evaluate whether p57KIP2 expression is concordant with the result of DNA polymorphism analysis in molar pregnancy. Eleven molar pregnancies diagnosed by pathologic findings between October 2002 and April 2004 were studied. Histopathologic diagnosis, DNA polymorphism analysis and p57KIP2 immunohistochemistry
Veli-Matti Marjoniemi
Pathology, 36(2), 109-119 (2004-06-19)
This paper reviews some aspects of the application of immunohistochemistry in gynaecological pathology. The use of cytokeratins 7 and 20 are discussed with reference to applications in ovarian pathology, including metastatic disease to the ovaries. Developments in utilising MIB-1 and
S-Y Jun et al.
Histopathology, 43(1), 17-25 (2003-06-26)
To determine the utility of p57kip2 in the diagnosis of hydatidiform mole. p57kip2 protein is a cyclin-dependent kinase inhibitor (CDKI) and is strongly paternally imprinted, being expressed from the maternal allele. It has been hypothesized that complete mole (CHM) with
Rita L Romaguera et al.
Fetal and pediatric pathology, 23(2-3), 181-190 (2005-03-17)
Classification of molar gestations into complete and partial and their differentiation from hydropic abortions traditionally are accomplished by morphology alone. The process sometimes may be inaccurate or inconclusive. With the availability of p57 immunostaining it may be possible to objectively
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