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462R-1

SF-1 (EP434) Rabbit Monoclonal Primary Antibody

Name: SF-1 (EP434) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

别名:

Steroidogenic Factor-1

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关于此项目

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP434, monoclonal

Application:

IHC (p)

Citations:

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属性

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP434, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (462R-14), vial of 0.1 mL concentrate Research Use Only (462R-14-RUO), vial of 0.5 mL concentrate (462R-15), vial of 1.0 mL concentrate (462R-16), vial of 1.0 mL concentrate Research Use Only (462R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (462R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (462R-17), vial of 7.0 mL pre-dilute ready-to-use (462R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (462R-18-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

adrenocortical carcionma, granulosa cell tumor, testis

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SF1(7536)

说明

General description

As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis. It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues. Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors. In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

法规信息

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Steroidogenic factor-1 and human disease.

Ranna El-Khairi et al.

Seminars in reproductive medicine, 30(5), 374-381 (2012-10-10)

Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that plays a key role in adrenal and reproductive development and function. Deletion of the gene encoding Sf-1 (Nr5a1) in mice results in severe developmental defects of the adrenal gland and

Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases.

Ankur R Sangoi et al.

The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)

The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic

Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases.