46393
Fluo-3
suitable for fluorescence, ~70%
别名:
4-(2,7-二氯-6-羟基-3-氧代-9-二苯基)-4′-甲基-2,2′-(亚乙二氧基)二苯胺-N,N,N′,N′-四乙酸
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关于此项目
经验公式（希尔记法）:
C36H30Cl2N2O13
化学文摘社编号:
分子量:
769.54
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
Fluo-3, suitable for fluorescence, ~70%
InChI
1S/C36H30Cl2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50)
SMILES string
Cc1ccc(N(CC(O)=O)CC(O)=O)c(OCCOc2cc(ccc2N(CC(O)=O)CC(O)=O)C3=C4C=C(Cl)C(=O)C=C4Oc5cc(O)c(Cl)cc35)c1
InChI key
OZLGRUXZXMRXGP-UHFFFAOYSA-N
assay
~70%
form
solid
solubility
H2O: soluble
fluorescence
λex 506 nm; λem 526 nm in 0.1 M Tris pH 8.0, esterase 30 mM Ca2+
suitability
suitable for fluorescence
storage temp.
−20°C
Quality Level
Application
Fluo-3和相关分子Fluo3/AM可用作细胞内钙离子（Ca2+）的荧光指示剂。Fluo-3可用于流式细胞术以及使用可见光激发的共焦激光扫描显微术（与在488nm下操作的氩激光源兼容）。与钙结合后，荧光强度增加约40倍。
Other Notes
用于流式细胞术的钙离子荧光指示剂。与钙结合后，荧光强度增加约40倍
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P A Vandenberghe et al.
Journal of immunological methods, 127(2), 197-205 (1990-03-09)
Cytoplasmic free calcium [( Ca2+]i) is a key intracellular messenger in many cell types. We have used fluo-3, a recently developed calcium probe, to study [Ca2+]i in resting and stimulated human peripheral blood T lymphocytes. The spectral properties of fluo-3
Yi Zheng et al.
Contact dermatitis, 81(3), 184-193 (2019-04-23)
Retinoic acid (RA)-induced dermatitis is the most frequent side-effect limiting its widespread use. However, the exact mechanisms triggering dermatitis are not fully understood, including the role of skin mast cells. The newly discovered Mas-related G-protein-coupled receptor-X2 (MRGPRX2) in mast cells
Qijin Zhao et al.
Cell death and differentiation, 26(9), 1600-1614 (2018-11-06)
Mitochondrial superoxide dismutase 2 (SOD2) is a major antioxidant defense enzyme. Here we provide evidence that SOD2 plays critical roles in maintaining calcium homeostasis in newly generated embryonic cerebral cortical neurons, which is essential for normal mitochondrial function and subcellular
Li-Yan Zhao et al.
Acta pharmacologica Sinica, 39(5), 875-884 (2018-03-30)
Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. (No 2508). We previously showed that Xyl-B promoted endothelial NO release and protected against atherosclerosis through the Akt/eNOS pathway. Vascular NO production regulates vasoconstriction in central
A Minta et al.
The Journal of biological chemistry, 264(14), 8171-8178 (1989-05-15)
A new group of fluorescent indicators with visible excitation and emission wavelengths has been synthesized for measurements of cytosolic free Ca2+. The five compounds, "rhod-1," "rhod-2," "fluo-1," "fluo-2," and "fluo-3" (Figs. 2 and 3), combine the 8-coordinate tetracarboxylate chelating site
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