主要文件

查看所有文档

468R-1

Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody

Name: Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP417, monoclonal

Application:

IHC (p)

Citations:

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP417, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (468R-14), vial of 0.1 mL concentrate Research Use Only (468R-14-RUO), vial of 0.5 mL concentrate (468R-15), vial of 1.0 mL concentrate (468R-16), vial of 1.0 mL concentrate Research Use Only (468R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (468R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (468R-17), vial of 7.0 mL pre-dilute ready-to-use (468R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (468R-18-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)

isotype

IgG

control

lung adenocarcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... CLDN4(1364)

说明

General description

The claudin-family proteins are a group of tight-junction membranous proteins responsible for paracellular molecular flow between adjacent cells of the epithelium.¹ In normal kidney, claudin-4 plays a key role in paracellular ion reabsorption.² Claudin-4 is expressed in most epithelial cells yet is absent in mesothelial cells, making it of great use in characterizing epithelial malignincies.³ Immunohistochemical identification of this antigen may help identify poorly differentiated lung adenocarcinoma from lesions of mesothelial origin.⁴ Likewise, identification of claudin-4 expression by IHC may be useful in characterizing breast and endometrial lesions.^5,6

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Analysis Note

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Still not finding the right product?

Explore all of our products under

— 或者 —

试用我们的产品选型工具工具缩小选择范围

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

法规信息

监管及禁止进口产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000504244

0000504239

0000504232

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells.

Xin Cong et al.

Journal of cell science, 128(12), 2271-2286 (2015-05-08)

The epithelial cholinergic system plays an important role in water, ion and solute transport. Previous studies have shown that activation of muscarinic acetylcholine receptors (mAChRs) regulates paracellular transport of epithelial cells; however, the underlying mechanism is still largely unknown. Here

Claudin-4 as therapeutic target in cancer.

A Neesse et al.

Archives of biochemistry and biophysics, 524(1), 64-70 (2012-01-31)

Intercellular junctional complexes such as adherens junctions and tight junctions are critical regulators of cellular polarity, paracellular permeability and metabolic and structural integrity of cellular networks. Abundant expression analysis data have yielded insights into the complex pattern of differentially expressed

Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer.

Gottfried E Konecny et al.

Gynecologic oncology, 109(2), 263-269 (2008-03-04)

Tight junction (TJ) proteins claudin-3 and claudin-4 may be differentially expressed in uterine serous papillary carcinoma (USPC), a rare form of endometrial cancer characterized by a particularly poor prognosis. Our aim was to determine the expression pattern and prognostic relevance

查看所有相关文献

全球贸易项目编号

货号	GTIN
468R-16-RUO	04061841853701