主要文件

查看所有文档

475R-9

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

Name: INSM1 (MRQ-70) Rabbit Monoclonal Antibody
Brand: SIGMA

别名:

Insulinoma-associated protein 1

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

MRQ-70, monoclonal

Application:

IHC (p)

Citations:

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-70, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (475R-94), vial of 0.1 mL concentrate Research Use Only (475R-94-RUO), vial of 0.5 mL concentrate (475R-95), vial of 1.0 mL concentrate (475R-96), vial of 1.0 mL concentrate Research Use Only (475R-96-RUO), vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO), vial of 1.0 mL pre-dilute ready-to-use (475R-97), vial of 7.0 mL pre-dilute ready-to-use (475R-98), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

pancreas

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

说明

General description

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor¹. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract^2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression^5-6.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Still not finding the right product?

试用我们的产品选型工具工具缩小选择范围

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000502416

0000493759

0000493760

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.

Mathias S Gierl et al.

Genes & development, 20(17), 2465-2478 (2006-09-05)

The pancreatic and intestinal primordia contain epithelial progenitor cells that generate many cell types. During development, specific programs of gene expression restrict the developmental potential of such progenitors and promote their differentiation. The Insm1 (insulinoma-associated 1, IA-1) gene encodes a

Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex.

Lilla M Farkas et al.

Neuron, 60(1), 40-55 (2008-10-23)

Basal (intermediate) progenitors are the major source of neurons in the mammalian neocortex. The molecular machinery governing basal progenitor biogenesis is unknown. Here, we show that the zinc-finger transcription factor Insm1 (insulinoma-associated 1) is expressed specifically in progenitors undergoing neurogenic

Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections.

Sanjay Mukhopadhyay et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(1), 100-109 (2018-08-30)

Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of

查看所有相关文献

全球贸易项目编号

货号	GTIN
475R-96-RUO	04061842188376