47729
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸
≥99.0% (TLC), BioXtra
别名:
N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸, fMLF, fMLP（用词错误，但已被广泛使用）, 趋化肽
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关于此项目
经验公式（希尔记法）:
C21H31N3O5S
化学文摘社编号:
分子量:
437.55
Beilstein:
2315783
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸, BioXtra, ≥99.0% (TLC)
产品线
BioXtra
质量水平
方案
≥99.0% (TLC)
表单
powder
颜色
white
溶解性
DMF: 50 mg/mL, clear, colorless
应用
cell analysis
储存温度
2-8°C
SMILES字符串
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChI key
PRQROPMIIGLWRP-BZSNNMDCSA-N
基因信息
human ... FPR1(2357)
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Amino Acid Sequence
NFor-Met-Leu-Phe
应用
1.第4和第5应用无法访问
2.第3应用不相关。
2.第3应用不相关。
生化/生理作用
N-甲酰基-Met-Leu-Phe是一种有效的趋化肽和甲酰肽受体（FPR）激动剂，可诱导巨噬细胞的代谢爆发，伴随呼吸四氯、溶酶体酶分泌和超氧阴离子产生的增加。
有效的趋化肽。诱导巨噬细胞的代谢爆发，并伴随着呼吸速率的增加、溶酶体酶的分泌以及超氧阴离子的产生。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Astrid L Voskamp et al.
The journal of allergy and clinical immunology. In practice, 3(2), 192-199 (2015-02-03)
Allergic bronchopulmonary aspergillosis (ABPA) often presents with persistently uncontrolled asthma despite the use of corticosteroids and antifungal therapy. Omalizumab is a humanized anti-IgE monoclonal antibody currently used to treat severe asthma. The aim was to assess the clinical and immunologic
C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology.
J James B Edelman et al.
Shock (Augusta, Ga.), 39(2), 149-154 (2013-01-18)
Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without
Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
Lunhua Liu et al.
Molecular biology of the cell, 23(24), 4751-4765 (2012-10-26)
Integrin activation is required to facilitate multiple adhesion-dependent functions of neutrophils, such as chemotaxis, which is critical for inflammatory responses to injury and pathogens. However, little is known about the mechanisms that mediate integrin activation in neutrophils. We show that
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