47752
芒柄花素
≥99.0% (TLC)
别名:
7-羟基-3-（4-甲氧基苯基）-4-H-1-苯并吡喃-4-酮, 7-羟基-3-（4-甲氧基苯基）色酮, 7-羟基-4′-甲氧基异黄酮, 刺芒柄花素, 刺芒柄花醇, 大豆苷元-4′-甲基醚, 鹰嘴豆素B
质量水平
方案
≥99.0% (TLC)
表单
solid
mp
257-261 °C
应用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES字符串
COc1ccc(cc1)C2=COc3cc(O)ccc3C2=O
InChI
1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
InChI key
HKQYGTCOTHHOMP-UHFFFAOYSA-N
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一般描述
芒柄花素是一种O-甲基化异黄酮，是植物雌激素。它见于许多豆科植物、不同种类三叶草（主要是红三叶草），是黄芪（Astragalus membranaceus）中发现的主要黄酮类化合物之一。
应用
芒柄花素已用作：
- 参考标准品，以使用液相色谱-光电二极管阵列-高分辨率质谱（LC-PDA-HRMS）技术研究藏红花柱头提取物中多种代谢物的出口。
- 植物雌激素异黄酮，以利用化学发光法在仿生环境下测试植物雌激素异黄酮的抗氧化作用
- 真正标准品，以采用高效液相色谱法测定野生型和转基因苜蓿植株的异黄酮含量。
- 利用不同的角质细胞系和人体皮肤当量（HSE）模型，测试作为潜在芳烃受体（AhR）激动剂对特应性皮炎（AD）治疗皮肤屏障蛋白恢复的影响
生化/生理作用
异黄酮在红三叶草中发现。可通过（至少部分通过）诱导肠粘膜中滋养体的分离，有效对抗 贾第鞭毛虫 的感染。
芒柄花素具有抗氧化、抗炎、抗高脂血症和保护心脏的作用。它显示出抗糖尿病特性，已知对 2 型糖尿病肾病有效。芒柄花素是一种著名的抗癌和化疗药物，用于癌症治疗。它还具有抗菌、神经保护和抗高血压的特性。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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