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Merck
CN

477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

别名:

Melanoma-associated antigen C2

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP405, monoclonal
Application:
IHC (p)
Citations:
7

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP405, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (477R-14), vial of 0.1 mL concentrate Research Use Only (477R-14-RUO), vial of 0.5 mL concentrate (477R-15), vial of 1.0 mL concentrate (477R-16), vial of 1.0 mL concentrate Research Use Only (477R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (477R-17), vial of 7.0 mL pre-dilute ready-to-use (477R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

isotype

IgG

control

seminoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Quality Level

100, 500

General description

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.4 In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.5-7

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000388097
0000388097
0000388089
0000388089

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Annikka Weissferdt et al.
Human pathology, 46(3), 376-383 (2015-01-13)
Primary mediastinal seminomas are unusual tumors that can present in a pure form or as part of a mixed germ cell tumor. Contrary to testicular seminomas, little is known about the expression of novel immunohistochemical markers in mediastinal seminomas. This
Ran Zhuang et al.
Cancer immunity, 6, 7-7 (2006-04-06)
CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our knowledge is based mainly on mRNA expression data. In
Yao-Tseng Chen et al.
Human reproduction (Oxford, England), 26(12), 3232-3243 (2011-10-22)
Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined. The expression of 10 CT-X antigens (MAGEA, NY-ESO-1
Peter K Bode et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 829-835 (2011-07-23)
Melanoma-associated gene C2 (MAGEC2) is a recently identified cancer testis antigen expressed in normal testicular and placental tissue. It has been detected in some human carcinomas, but its expression in primary testicular germ cell tumors is unknown. Immunohistochemistry was used
Anna K Lee et al.
Journal of molecular biology, 429(8), 1114-1142 (2017-03-17)
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more
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