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Merck
CN

483R-1

p40 (ZR8) Rabbit Monoclonal Antibody

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
ZR8
Application:
IHC (p)
Citations:
8

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

ZR8

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (483R-14), vial of 0.1 mL concentrate, Research Use Only (483R-14-RUO), vial of 0.5 mL concentrate (483R-15), vial of 1.0 mL concentrate (483R-16), vial of 1.0 mL concentrate, Research Use Only (483R-16-RUO), vial of 1.0 mL pre-dilute, Research Use Only (483R-17-RUO), vial of 1.0 mL pre-dilute, ready to use (483R-17), vial of 25.0 mL pre-dilute, ready-to-use (483R-10), vial of 25.0 mL pre-dilute, ready-to-use, Research Use Only (483R-10-RUO), vial of 7.0 mL pre-dilute, ready to use (483R-18), vial of 7.0 mL pre-dilute, ready to use, Research Use Only (483R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

Quality Level

100, 500

control

lung (squamous cell carcinoma), prostate, urothelial carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

相关类别

General description

p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland.1-5 Strong p40 expression is frequently observed in esophageal cancerous squamous lesions.6 Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma.7 In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining.8

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Analysis Note

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000492796
0000492796
0000491211
0000491274
0000491211

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Helene Geddert et al.
Human pathology, 34(9), 850-856 (2003-10-17)
p63, a member of the p53 gene family, is known to encode functionally antagonistic protein isoforms. Although transactivating protein isoforms display p53-like functions, deltaNp63 isoforms act toward p53 in a dominant negative way. Using immunohistochemistry, we examined the expression of
Khairunisa Ahmad Affandi et al.
Journal of pathology and translational medicine, 52(5), 283-289 (2018-09-22)
Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become
Hermann Brustmann
Pathology research international, 2015, 897927-897927 (2015-04-09)
Immunohistochemistry is important for the accurate diagnosis of basal cells in atypical glandular proliferations of the prostate. p40, an isoform of p63, may be an adjunct to a marker panel in this setting. Biopsies of 68 patients were analyzed by
Ahmed K Alomari et al.
Journal of cutaneous pathology, 41(11), 839-845 (2014-09-30)
Poorly differentiated squamous cell carcinoma (SCC) of the skin may pose a diagnostic challenge for pathologists. p40 is a recently introduced antibody that recognizes specific p63 protein isoforms and has shown superior results labeling non-cutaneous SCC. We hypothesize that p40
Giuseppe Pelosi et al.
Expert review of respiratory medicine, 10(10), 1105-1121 (2016-09-13)
To highlight the role of immunohistochemistry to lung cancer classification on the basis of existing guidelines and future perspectives. Four orienting key-issues were structured according to an extensive review on the English literature: a) cancer subtyping; b) best biomarkers and
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