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Merck
CN

486R-1

Somatostatin Receptor 2A (EP149) Rabbit Monoclonal Primary Antibody

别名:

SSTR2A

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关于此项目

UNSPSC Code:
41116161
Conjugate:
unconjugated
Clone:
EP149
Application:
IHC
Citations:
5

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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

EP149

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL (concentrate (486R-14)), vial of 0.1 mL (concentrate (486R-14-RUO) Research Use Only), vial of 0.5 mL (concentrate (486R-15)), vial of 1.0 mL (concentrate (486R-16)), vial of 1.0 mL (concentrate (486R-16-RUO) Research Use Only), vial of 1.0 mL (pre-dilute (486R-17-RUO) Research Use Only), vial of 1.0 mL (pre-dilute ready-to-use (486R-17)), vial of 7.0 mL (pre-dilute ready-to-use (486R-18)), vial of 7.0 mL (pre-dilute ready-to-use (486R-18-RUO) Research Use Only)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

isotype

IgG

control

lymph node, pancreas, (meningioma)

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic (
), membranous

Quality Level

500

General description

Somatostatin Receptor 2A (SSTR2A) is a protein highly expressed in pancreas binding somatostatin and inhibiting pancreatic enzyme secretion. SSTR2A is used as a marker for identifying meningioma from other spindle-cell tumors such as solitary fibrous tumor. SSTR2A is more frequently expressed in higher grade meningiomas and associated to its microvessel proliferation. SSTR2A has demonstrated utility as a diagnostic marker for follicular dendritic cell sarcomas and some other related tumors.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

法规信息

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分析证书(COA)

Lot/Batch Number
0000502779
0000502779
0000502781
0000502781
0000505172

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Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.
Joshua R Menke et al.
Acta neuropathologica, 130(3), 441-443 (2015-07-22)
Li-Li Tao et al.
The American journal of surgical pathology, 43(3), 374-381 (2018-12-27)
SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess
Camille Boulagnon-Rombi et al.
Journal of neuropathology and experimental neurology, 76(4), 289-298 (2017-03-25)
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA)
V Barresi et al.
Oncology reports, 20(3), 485-492 (2008-08-13)
Somatostatin anti-proliferative and anti-angiogenic activities, together with the expression of somatostatin receptors (sstrs), account for the use of somatostatin analogues in the treatment of human tumours. In the present study, sstr2A immunohistochemical expression was analyzed in grade II and III
Balrik Kailey et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1107-E1116 (2012-08-31)
Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1-5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR

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