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Merck
CN

486R-1

Sigma-Aldrich

Somatostatin Receptor 2A (EP149) Rabbit Monoclonal Primary Antibody

别名:

SSTR2A

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UNSPSC代码:
41116161

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生物来源

rabbit

质量水平

500

偶联物

unconjugated

抗体形式

IgG fraction of antiserum

抗体产品类型

primary antibodies

克隆

EP149

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL (concentrate (486R-14))
vial of 0.1 mL (concentrate (486R-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (486R-15))
vial of 1.0 mL (concentrate (486R-16))
vial of 1.0 mL (concentrate (486R-16-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (486R-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (486R-17))
vial of 7.0 mL (pre-dilute ready-to-use (486R-18))
vial of 7.0 mL (pre-dilute ready-to-use (486R-18-RUO) Research Use Only)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

同位素/亚型

IgG

控制

lymph node, pancreas, (meningioma)

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic (
), membranous

一般描述

Somatostatin Receptor 2A (SSTR2A) is a protein highly expressed in pancreas binding somatostatin and inhibiting pancreatic enzyme secretion. SSTR2A is used as a marker for identifying meningioma from other spindle-cell tumors such as solitary fibrous tumor. SSTR2A is more frequently expressed in higher grade meningiomas and associated to its microvessel proliferation. SSTR2A has demonstrated utility as a diagnostic marker for follicular dendritic cell sarcomas and some other related tumors.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

分析说明

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000438605
0000438600
0000438600
0000438605
0000438585

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Camille Boulagnon-Rombi et al.
Journal of neuropathology and experimental neurology, 76(4), 289-298 (2017-03-25)
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA)
Li-Li Tao et al.
The American journal of surgical pathology, 43(3), 374-381 (2018-12-27)
SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess
V Barresi et al.
Oncology reports, 20(3), 485-492 (2008-08-13)
Somatostatin anti-proliferative and anti-angiogenic activities, together with the expression of somatostatin receptors (sstrs), account for the use of somatostatin analogues in the treatment of human tumours. In the present study, sstr2A immunohistochemical expression was analyzed in grade II and III
Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.
Joshua R Menke et al.
Acta neuropathologica, 130(3), 441-443 (2015-07-22)
Balrik Kailey et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1107-E1116 (2012-08-31)
Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1-5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR

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