biological source
rabbit
Quality Segment
antibody product type
primary antibodies
clone
MRQ-72, monoclonal
description
For In Vitro Diagnostic Use in Select Regions
packaging
vial of 0.1 mL concentrate (487R-94), vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only, vial of 0.5 mL concentrate (487R-(95), vial of 1.0 mL (concentrate (487R-96)), vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only, vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only, vial of 1.0 mL pre-dilute ready-to-use (487R-97), vial of 7.0 mL pre-dilute ready-to-use (487R-98), vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only
manufacturer/tradename
Cell Marque®
isotype
IgG
control
pancreas
visualization
cytoplasmic, nuclear
General description
Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon. However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.
Note: This requires a keycode which can be found on your packaging or product label.
Analysis Note
IVD - MQ500
RUO - MQ100
RUO - MQ100
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2