biological source
rabbit
antibody product type
primary antibodies
clone
MRQ-72, monoclonal
description
For In Vitro Diagnostic Use in Select Regions
packaging
vial of 0.1 mL concentrate (487R-94), vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only, vial of 0.5 mL concentrate (487R-(95), vial of 1.0 mL (concentrate (487R-96)), vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only, vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only, vial of 1.0 mL pre-dilute ready-to-use (487R-97), vial of 7.0 mL pre-dilute ready-to-use (487R-98), vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only
manufacturer/tradename
Cell Marque®
isotype
IgG
control
pancreas
visualization
cytoplasmic, nuclear
Quality Level
General description
Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon. However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.
Note: This requires a keycode which can be found on your packaging or product label.
Analysis Note
IVD - MQ500
RUO - MQ100
RUO - MQ100
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
法规信息
监管及禁止进口产品
此项目有
Y H Kim et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 15(4), 574-580 (2004-03-23)
Transforming growth factor-beta (TGF-beta) modulates the growth and function of many cells, including those with malignant transformation. Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members. To clarify the correlations between clinicopathologic profiles
R Salovaara et al.
Gut, 51(1), 56-59 (2002-06-22)
Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a
K L Woodford-Richens et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(17), 9719-9723 (2001-08-02)
Loss of chromosome 18q21 is well documented in colorectal cancer, and it has been suggested that this loss targets the DCC, DPC4/SMAD4, and SMAD2 genes. Recently, the importance of SMAD4, a downstream regulator in the TGF-beta signaling pathway, in colorectal
Michael Torbenson et al.
Human pathology, 33(9), 871-876 (2002-10-16)
In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A
Lauren L Ritterhouse et al.
Histopathology, 75(4), 546-551 (2019-05-06)
SMAD4 (DPC4) is a tumour suppressor gene that is dysregulated in various tumour types, particularly pancreaticobiliary and gastrointestinal carcinomas. Corresponding loss of protein expression has been reported in approximately 50% of pancreatic and 25% of colonic adenocarcinomas. In the evaluation
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