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Merck
CN

490M-1

Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody

别名:

TYH

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关于此项目

UNSPSC Code:
41116161
Conjugate:
unconjugated
Clone:
LNC1
Application:
IHC
Citations:
4

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biological source

(Mouse)

conjugate

unconjugated

antibody form

(IgG1 Supernatant)

antibody product type

primary antibodies

clone

LNC1

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL (concentrate (490M-14)), vial of 0.1 mL (concentrate (490M-14-RUO) Research Use Only), vial of 0.5 mL (concentrate (490M-15)), vial of 1.0 mL (concentrate (490M-16)), vial of 1.0 mL (concentrate (490M-16-RUO) Research Use Only), vial of 1.0 mL (pre-dilute (490M-17-RUO) Research Use Only), vial of 1.0 mL (pre-dilute ready-to-use (490M-17)), vial of 7.0 mL (pre-dilute ready-to-use (490M-18)), vial of 7.0 mL (pre-dilute ready-to-use (490M-18-RUO) Research Use Only)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

isotype

IgG1

control

neuroblastoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Quality Level

500

General description

Tyrosine Hydroxylase (TYH) is the rate-limiting enzyme of catecholamine biosynthesiss. TYH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-DOPA, a precursor to dopamine. Anti-TYH is sensitive and specific for peripheral neuroblastic tumors in the differential diagnosis from other tumors of childhood and shows high diagnostic utility. Anti-TYH has been shown to positively label all pheochromocytomas and sympathetic paragangliomas, and thus aids in differentiating them from their histologic mimics such as adrenocortical neoplasms.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000505148
0000507259
0000517391
0000517391
0000505148

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Junkichi Takemoto et al.
Human pathology, 85, 162-167 (2018-11-24)
The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas
L A Loizou
British journal of pharmacology, 41(1), 41-48 (1971-01-01)
1. Tyrosine hydroxylase is thought to be the rate limiting enzyme step in catecholamine biosynthesis. Inhibition of this enzyme using alpha-methyl-p-tyrosine resulted in a time dependent depletion (and repletion) of formaldehyde induced fluorescence in catecholamine-containing neurones of the central nervous
S Colette Daubner et al.
Archives of biochemistry and biophysics, 508(1), 1-12 (2010-12-24)
Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. Modes of
Mikako Warren et al.
Histopathology, 72(4), 685-696 (2017-10-08)
This study evaluated the utility of Phox2b in paediatric tumours. Previously, tyrosine hydroxylase (TH) was the most widely utilised sympathoadrenal marker specific for neural crest tumours with neuronal/neuroendocrine differentiation. However, its sensitivity is insufficient. Recently Phox2b has emerged as another

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