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50239

甘氨酸

Name: 甘氨酸
Brand: SIGMA

≥99.0% (NT), suitable for ligand binding assays, BioUltra

别名:

三甘氨酸, 甘氨酰-甘氨酰-甘氨酸

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关于此项目

线性分子式:

NH₂CH₂CONHCH₂CONHCH₂COOH

化学文摘社编号:

556-33-2

分子量:

189.17

NACRES:

NA.26

PubChem Substance ID:

57651245

UNSPSC Code:

12352209

EC Number:

209-122-0

MDL number:

MFCD00036223

Beilstein/REAXYS Number:

1711130

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属性

产品名称

甘氨酸, BioUltra, ≥99.0% (NT)

product line

BioUltra

Quality Level

100

assay

≥99.0% (NT)

form

powder

technique(s)

ligand binding assay: suitable

impurities

insoluble matter, passes filter test

ign. residue

≤0.1% (as SO₄)

loss

≤0.5% loss on drying, 110 °C

color

white

pH

4.5-6.0 (25 °C, 0.5 M in H₂O)

solubility

H₂O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤50 mg/kg, Bi: ≤5 mg/kg, Ca: ≤20 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

λ

0.5 M in H₂O

UV absorption

λ: 260 nm A_max: 0.15, λ: 280 nm A_max: 0.10

SMILES string

NCC(=O)NCC(=O)NCC(O)=O

InChI

1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)

InChI key

XKUKSGPZAADMRA-UHFFFAOYSA-N

说明

General description

甘氨酸-甘氨酸-甘氨酸或三甘氨酸是一种由三个甘氨酸残基组成的柔性多肽接头，由肽键按线性顺序连接而成。甘氨酸接头连接单一蛋白的多个结构域，而不影响每个结构域的功能。

Application

<ul>
<li><strong>靶向PEPT1：提高阿霉素在人肝细胞癌治疗中抗肿瘤疗效的新策略：</strong>研究探索将Gly-Gly-Gly肽用作药物递送效率的潜在增强剂，将其定位为癌症靶向治疗用临床诊断肽开发的宝贵工具（Gong et al., 2017）。</li>
<li><strong>氨基酯甲基丝氨酸和Gly-Gly、Gly-Val和Gly-Gly-Gly肽衍生的亚氨基吡啶锰、铼和钼配合物：肽链的自组装：</strong>本研究展示了Gly-Gly-Gly在复杂金属肽框架合成中的应用，可能用于IVD生产中的高纯度肽应用（Álvarez et al., 2012）。</li>
</ul>

Biochem/physiol Actions

用于通过缩二脲反应重现血清蛋白测量和测定氨基三肽酶的底物。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Linkers in the structural biology of protein-protein interactions.

Vishnu Priyanka Reddy Chichili et al.

Protein science : a publication of the Protein Society, 22(2), 153-167 (2012-12-12)

Linkers or spacers are short amino acid sequences created in nature to separate multiple domains in a single protein. Most of them are rigid and function to prohibit unwanted interactions between the discrete domains. However, Gly-rich linkers are flexible, connecting

Dipositively charged protonated a3 and a2 ions: generation by fragmentation of [La(GGG)(CH3CN)2]3+.

Tujin Shi et al.

Angewandte Chemie (International ed. in English), 47(43), 8288-8291 (2008-09-26)

Investigation of protein conformation and interactions with salts via X-ray absorption spectroscopy.

Craig P Schwartz et al.

Proceedings of the National Academy of Sciences of the United States of America, 107(32), 14008-14013 (2010-07-28)

Nitrogen K-edge spectra of aqueous triglycine were measured using liquid microjets, and the effects of Hofmeister-active salts on the spectra were observed. Spectra simulated using density functional theory, sampled from room temperature classical molecular dynamics trajectories, capture all major features

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全球贸易项目编号

货号	GTIN
50239-1G	04061832422671
50239-5G	04061833355589