SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
mol wt
~9840-14600 g/mol
composition
oxyethylene content, 71.5-74.9%
impurities
≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤0.75% water
≤1 ppm ethylene oxide
≤2 ppm arsenic
≤20 ppm heavy metals
50-125 ppm butylhydroxytoluene
ign. residue
≤0.30%
color
APHA: ≤120
particle size distribution
, coeff var ≤10% (residue, No. 140 USS)
, coeff var ≤50% (residue, No. 270 USS)
pH
5.0-7.5(1:10)
5.0-7.5(1:40)
suitability
complies for Infrared spectrum
Quality Level
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Analysis Note
残留溶剂（GLC-HS）
1,4-二恶烷 ≤5 ppm，乙二醇 ≤620 ppm（仅在随机样品上验证）
1,4-二恶烷 ≤5 ppm，乙二醇 ≤620 ppm（仅在随机样品上验证）
Application
Poloxamer 407是广泛的Pluronic®嵌段共聚物系列泊洛沙姆(poloxamer)的一种型号。广泛用作增稠剂和凝胶粘合剂。
Other Notes
平均分子量/质量 9840-14600 g/mol；平均分子量 10000-14600 g/mol
Legal Information
Pluronic is a registered trademark of BASF
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
V K Zhalimov et al.
Biofizika, 57(2), 308-316 (2012-05-19)
It has been shown that sorption of most proteins with the molecular weight lower than 200 kDa from human blood plasma on the surface of perfluorocarbon emulsion, stabilized with proxanol 268, is mainly based on hydrophobic interaction, whereas sorption of
Liyan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
Laurien Buitinga et al.
Clinical and experimental rheumatology, 29(5), 783-789 (2011-10-04)
The Time Trade-Off (TTO) is an instrument used for valuing health-related quality of life. This study evaluated the test-retest reliability of a computer TTO in rheumatoid arthritis (RA), and compared the computer with the interview TTO regarding feasibility and agreement.
Yanbin Guan et al.
Archives of pharmacal research, 34(10), 1719-1728 (2011-11-15)
The aim of the present study was to evaluate the effect of pluronic P123 (P123) and pluronic F127 (F127) on intestinal P-glycoprotein (P-gp) and cytochrome P450 3A using the specific substrates rhodamine-123 (R-123) and midazolam, respectively. Caco-2 cells and everted
A Kiwilsza et al.
Journal of microencapsulation, 30(1), 21-27 (2012-06-09)
Mesoporous material SBA-15 of hexagonal structure was synthesised and its usefulness as a carrier for a poorly soluble drug--lacidipine (LA)--was tested. The source of silica was tetraethyl orthosilicate (TEOS) and the structure ordering agent was non-ionic surfactant Pluronic P123. SBA-15
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