50838
（R）-甲羟戊酸 锂盐
≥93.0% (qNMR)
别名:
R-MVA-Li, （R）-3，5-二羟基-3-甲基戊酸锂
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关于此项目
经验公式（希尔记法）:
C6H11LiO4
化学文摘社编号:
分子量:
154.09
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥93.0% (qNMR)
assay
≥93.0% (qNMR)
optical activity
[α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h)
storage temp.
2-8°C
SMILES string
[Li+].C[C@@](O)(CCO)CC([O-])=O
InChI
1S/C6H12O4.Li/c1-6(10,2-3-7)4-5(8)9;/h7,10H,2-4H2,1H3,(H,8,9);/q;+1/p-1/t6-;/m1./s1
InChI key
PVWNXFFXFNEHDZ-FYZOBXCZSA-M
Application
甲羟戊酸可用作分离或检测甲羟戊酸试验中的参考材料。甲羟戊酸是异戊烯焦磷酸（IPP）和甲羟戊酸途径的前体，它可以引导类异戊二烯生物的合成。甲羟戊酸可用作鉴定和表征甲羟戊酸激酶的底物。
Biochem/physiol Actions
甲羟戊酸是甲羟戊酸途径中的中间体，产生萜烯和类固醇。该功能提供治疗选择为常染色体隐性遗传甲羟戊酸尿症（一种胆固醇和非甾醇异戊二烯生物合成的先天性错误）患者的代谢紊乱 、R-甲羟戊酸累积提供了治疗选项。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Enantiomerically pure phosphonate analogues of cis- and trans-4-hydroxyprolines.
Cornforth, R. H., et al.
Tetrahedron, 18, 1351-1354 (1962)
A Scoppola et al.
Kidney international, 51(3), 908-912 (1997-03-01)
Mevalonic acid (mevalonate or MVA), is an obligate precursor in the biosynthetic pathway of cholesterol. It is partially metabolized by the kidneys and its plasma concentrations are an index of endogenous cholesterol synthesis. The aim of the present study was
S M Houten et al.
Cellular and molecular life sciences : CMLS, 60(6), 1118-1134 (2003-07-16)
Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is demonstrated by the identification of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 50838-50MG | 04061832489483 |
| 50838-10MG | 04061832404486 |