InChI key
IUAYMJGZBVDSGL-JYFSIOBESA-N
SMILES string
CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](Cc5ccccc5)NC1=O)C(C)C)C(C)C
biological source
Bacillus brevis
assay
~90% (HPLC)
form
powder
impurities
≤5% water
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell membrane | interferes, enzyme | inhibits
storage temp.
2-8°C
Quality Level
General description
Chemical structure: peptide
Application
Gramicidin is a naturally occuring polypeptide antibiotic. It functions as a transmembrane ion channel and is used for studies on phospholipid bilayer membrane fluidity measured by lateral diffusion.
Biochem/physiol Actions
Gramicidin′s bactericidal activity is a result of increasing the permeability of the bacterial cell membrane. This allows inorganic monovalent cations to travel through unrestricted which thereby destroys the ion gradient between the cytoplasm and the extracellular environment .
Naturally occuring polypeptide antibiotic with Tyr at position 11; functions as a transmembrane ion channel.
Packaging
10mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. Keep in a dry place.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
G.A. Brewer
Anal. Profiles Drug Subst., 8, 179-179 (1979)
Dong Hyeon Lee et al.
Yonsei medical journal, 49(3), 459-471 (2008-06-27)
This study examined the expression and function of inward rectifier K(+) channels in cultured rat hepatic stellate cells (HSC). The expression of inward rectifier K(+) channels was measured using real-time RT-PCR, and electrophysiological properties were determined using the gramicidin-perforated patch-clamp
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases.
Francisco J. Alvarez-Leefmans; Eric Delpire
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases, 142-142 (2009)
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