51010
4-Methylumbelliferyl 4-guanidinobenzoate hydrochloride hydrate
≥85% (HPLC)
别名:
4-Guanidinobenzoic acid 4-methylumbelliferyl ester hydrochloride, MUGB
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关于此项目
经验公式（希尔记法）:
C18H15N3O4 · HCl · xH2O
化学文摘社编号:
分子量:
373.79 (anhydrous basis)
UNSPSC Code:
12352204
PubChem Substance ID:
EC Number:
251-871-0
MDL number:
InChI key
DAFWZROYEOVJAL-UHFFFAOYSA-N
InChI
1S/C18H15N3O4.ClH/c1-10-8-16(22)25-15-9-13(6-7-14(10)15)24-17(23)11-2-4-12(5-3-11)21-18(19)20;/h2-9H,1H3,(H4,19,20,21);1H
SMILES string
Cl[H].CC1=CC(=O)Oc2cc(OC(=O)c3ccc(NC(N)=N)cc3)ccc12
assay
≥85% (HPLC)
form
powder
fluorescence
λex 323 nm; λem 464 nm (solvent pH 6.0), λex 360 nm; λem 449 nm (Reaction Product)
storage temp.
2-8°C
Other Notes
Fluorimetric titrant for α- and β-trypsin, thrombin and Factor Xa
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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Some sensitive methods for the assay of trypsinlike enzymes.
P L Coleman et al.
Methods in enzymology, 45, 12-26 (1976-01-01)
G W Jameson et al.
The Biochemical journal, 131(1), 107-117 (1973-01-01)
Several esters of 4-methylumbelliferone and 2-naphthol were synthesized and examined as possible spectrofluorimetric titrants for bovine alpha-chymotrypsin, trypsin, thrombin, Factor Xa and for subtilisin Novo. 4-Methylumbelliferyl p-guanidinobenzoate hydrochloride (MUGB) is a satisfactory titrant for alpha- and beta-trypsin, thrombin and Factor
Lambro A Johnson et al.
Analytical biochemistry, 608, 113907-113907 (2020-08-20)
Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for thrombin. The coupled reactions result in accelerating p-nitroaniline (pNA) production
J Grandoni et al.
Haemophilia : the official journal of the World Federation of Hemophilia, 23(2), 300-308 (2016-12-21)
LR769 is a new second-generation recombinant human Factor VIIa (rhFVIIa) developed for haemophilia treatment. We determined enzymatic properties of LR769 and its interaction with antithrombin, tissue factor, platelets and endothelial protein C receptor (EPCR), compared with NovoSevenRT. Kinetic enzyme assays
Simon J de Veer et al.
The Biochemical journal, 469(2), 243-253 (2015-05-20)
Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesizing a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor's resistance to hydrolysis and
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