51060
5′-二磷酸鸟苷 二钠盐
≥90% (HPLC), from Porcine brain, powder
别名:
5′-GDP-Na2
产品名称
5′-二磷酸鸟苷 二钠盐, ≥90% (HPLC)
生物来源
Porcine brain
microbial (Corynebacterium sp)
synthetic
质量水平
方案
≥90% (HPLC)
表单
powder
溶解性
H2O: 50 mg/mL, clear, colorless
运输
dry ice
储存温度
−20°C
SMILES字符串
[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
InChI
1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
InChI key
LTZCGDIGAHOTKN-LGVAUZIVSA-L
相关类别
一般描述
鸟苷5′-二磷酸（GDP）是嘌呤核苷酸，可通过外切核苷酸酶的作用和核苷磷酸化为鸟嘌呤而相互转化为鸟苷。GDP主要受神经元细胞中5′-外切核苷酸酶的作用。
应用
鸟苷-5′-二磷酸二钠盐已用于：
- 鸟苷3′-二磷酸-5′-二(三)磷酸的荧光金属纳米团簇中的选择性，筛选小鼠脑切片放射自显影中测定缓冲液组分竹红菌甲素-锌复合物
- 的荧光发射中的ppGpp
鸟苷5′-二磷酸（GDP）用作丙酮酸激酶的底物以产生GTP以支持RNA生物合成。 GDP用于研究GTPases的动力学和特征，例如与G蛋白偶联受体（GPCR）相关的GTPases。GDP还用于研究鸟嘌呤核苷酸交换因子介导的细胞信号传导过程。
生化/生理作用
基于鸟苷的核苷在多种细胞过程和生成生长因子中起关键作用。鸟苷5′-二磷酸（GDP）水平升高与神经系统疾病的发病机理有关。GDP与G蛋白结合。G蛋白偶联受体（GPCR）通过将结合的GDP交换为GTP来激活G蛋白。GDP是铁调素-膜铁转运蛋白复合物的强效抑制剂，可能具有促进红细胞生成和治疗炎症性贫血（AI）的作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Angmo S, et al.
Scientific Reports, 7, 40097-40097 (2017)
The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase.
Vestal DJ, Jeyaratnam JA.
Interferon Cytokine Res., 31, 89-97 (2011)
Activation of G proteins by guanine nucleotide exchange factors relies on GTPase activity
Stanley RJ and Thomas GMH
PLoS ONE, 11(3), e0151861-e0151861 (2016)
Tomoya Saito et al.
The Journal of biological chemistry, 283(20), 14041-14052 (2008-03-08)
We previously reported a cytosolic pyruvate kinase (EC 2.7.1.40) from Toxoplasma gondii (TgPyKI) that differs from most eukaryotic pyruvate kinases in being regulated by glucose 6-phosphate rather than fructose 1,6-diphosphate. Another putative pyruvate kinase (TgPyKII) was identified from parasite genome
Michael P East et al.
Seminars in cell & developmental biology, 22(1), 3-9 (2010-07-20)
Arf GAPs (ADP-ribosylation factor GTPase-activating proteins) are essential components of Arf (ADP-ribosylation factor) signaling pathways. Arf GAPs stimulate the hydrolysis of GTP to GDP to transition Arf from the active, GTP bound, state to the inactive, GDP bound, state. Based
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