51120
5′-三磷酸鸟苷 钠盐 水合物
≥90% (HPLC), powder
别名:
GTP-Na⁺ 水合物, 5′-GTP-Na2
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关于此项目
经验公式（希尔记法）:
C10H16N5O14P3 · xNa+ · yH2O
化学文摘社编号:
分子量:
523.18 (anhydrous free acid basis)
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
252-847-2
MDL number:
Beilstein/REAXYS Number:
4113439
Assay:
≥90% (HPLC)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
5′-三磷酸鸟苷 钠盐 水合物, ≥90% (HPLC)
InChI key
HPLNHYUZFVUXFJ-ZVQJTLEUSA-L
InChI
1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1
SMILES string
O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
assay
≥90% (HPLC)
form
powder
optical activity
[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4
impurities
≤3 mol/mol water (NMR)
solubility
water: 50 mg/mL, clear, colorless
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
5′-三磷酸鸟苷(GTP)是一种嘌呤三核苷酸磷酸。GTP是各种G-蛋白偶联受体(GPCR)GTP酶及细胞信号转导和GTP/GDP循环相关鸟嘌呤核苷酸交换因子(GEF)的底物。如需进行RNA聚合酶转录、DNA/RNA生物合成，请访问G3776产品。
Application
鸟苷 5′-三磷酸钠盐水合物已用于：
- 作为星形胶质细胞膜片钳内液的组成部分，监测小鼠杏仁核切片星形胶质细胞的钙活性。
- 利用电压钳技术记录细胞系中通道电流的溶液。
- 制备内部记录注射溶液，用于将基因传递到机械感觉毛细胞。
- 在通过体积排除色谱法（SEC）分析齐聚反应过程中，促进G界面介导的人septin蛋白同源二聚体的形成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)
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Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)
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J Spychala et al.
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S P Gilbert et al.
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The Drosophila kinesin heavy-chain gene was truncated to obtain the N-terminal 401 amino acid motor domain (designated K401) containing both the microtubule and ATP binding sites. The plasmid construct with the truncated kinesin gene was used to transform Escherichia coli.
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