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Merck
CN

51280

氯化高铁血红素

BioXtra, from Porcine, ≥96.0% (HPLC)

别名:

氯(原卟啉酸)铁(III), 氯化血红素, 氯原卟啉IX铁(III), 高铁原卟啉IX氯, 高铁血红素(氯)

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关于此项目

经验公式(希尔记法):
C34H32ClFeN4O4
化学文摘社编号:
分子量:
651.94
UNSPSC Code:
12352202
NACRES:
NA.79
PubChem Substance ID:
EC Number:
240-140-1
Beilstein/REAXYS Number:
5229914
MDL number:
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产品名称

氯化高铁血红素, BioXtra, from Porcine, ≥96.0% (HPLC)

InChI key

BTIJJDXEELBZFS-HXFTUNQESA-K

InChI

1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

SMILES string

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Fe](Cl)n34)c(C=C)c5C

biological source

Porcine

product line

BioXtra

assay

≥96.0% (HPLC)

form

powder or crystals

technique(s)

tissue culture: suitable
transfection: suitable

storage temp.

2-8°C

Quality Level

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Application

高铁血红素应用于以下应用中:
  • 研究菌株和生长条件
  • 用于短期菌落测定(培养基由血红素和其他成分组成)
  • 细胞转染
它可用于分析MMV(抗疟药物)疟疾盒化合物对β-血红蛋白形成的抑制作用。

Biochem/physiol Actions

高铁血红素是经氧化血红素,是一系列蛋白质的一种含铁的辅基基团。游离血红素在溶血后从血红蛋白中释放出来,具有促炎作用,有助于铁源活性氧的生成。游离血红素水平可在各种病理条件下上调,并可导致各种炎症条件,包括血管疾病、肾功能衰竭和免疫介导的疾病。

高铁血红素可用于研究血红素加氧酶1 (HO-1)的表达和抑制以及HO-1的活性。 血凝素是生长流感嗜血杆菌所必需的“X因子”。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Product 51280, Hemin?

    Hemin can be dissolved in DMSO at 1 mM. This product should be soluble in 1.4 M ammonium hydroxide (50 mg/ml) with 5 minutes of heating at 95 °C, yielding a dark brown solution.  A stock solution of 0.25% hemin in 50% triethanolamine can be made.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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