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Merck
CN

51290

血红蛋白 来源于牛血液

lyophilized, 2×cryst., ≥90% (SDS-PAGE), powder

别名:

Hb, 牛血红蛋白, 高铁血红蛋白

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352202
MDL number:
Form:
powder
Assay:
≥90% (SDS-PAGE)
Biological source:
bovine blood
Mol wt:
Mr ~64500
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biological source

bovine blood

assay

≥90% (SDS-PAGE)

form

powder

quality

2×cryst., lyophilized

mol wt

Mr ~64500

technique(s)

UV/Vis spectroscopy: suitable

impurities

salt, none detected, ~0.3% Fe

loss

≤8% loss on drying

Quality Level

UniProt accession no.

storage temp.

2-8°C

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General description

Hemoglobin (Hb) is the protein responsible for storage and transport of oxygen and other gaseous ligands in red blood cells (RBC). Hb is also the pioneer material for synthesis of Hb-based oxygen carriers (HBOCs) that can be used as substitutes for RBC.

Application

α-弹性蛋白的溶解度已被应用于弹性蛋白模拟生物材料的构建。

Biochem/physiol Actions

氧气转运蛋白。Fe2+/Fe3+平衡是血液氧合的一种生理指标;脱氧血红蛋白通过将亚硝酸还原为NO来补充反馈回路,而NO是一种可增强血液流向缺氧组织流量的血管扩张剂。
氧转运体,NO 清除剂

Other Notes

Review: Oxygen carrier proteins
Sales restrictions may apply

Disclaimer

由于天然血红蛋白在空气中易于氧化,因此这些制剂主要为高铁血红蛋白。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Paul W Buehler et al.
Biomaterials, 31(13), 3723-3735 (2010-02-13)
Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs
M. Brunori et al.
Topics in Molecular and Structural Biology, 7, 263-263 (1985)
R Bokiniec et al.
Advances in medical sciences, 57(2), 348-355 (2012-11-20)
The aim of this study was to determine brain oxygenation in full-term and preterm neonates using near infrared spectroscopy. A total of 88 full-term and preterm newborn infants without hypoxic-ischaemic disorders admitted to the NICU were examined using NIRS on
Omar Falou et al.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012, 3155-3158 (2013-02-01)
The necessity for a non-invasive and inexpensive imaging modality to both diagnose and monitor treatment response has lead to renewed interest in the potential of optical imaging. The aim of this study was to investigate the potential of diffuse optical
Xiao-Su Hu et al.
Journal of biomedical optics, 18(1), 17003-17003 (2013-01-08)
The reduction of trial-to-trial variability (TTV) in task-evoked functional near-infrared spectroscopy signals by considering the correlated low-frequency spontaneous fluctuations that account for the resting-state functional connectivity in the brain is investigated. A resting-state session followed by a task-state session of

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