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Merck
CN

54880

Sigma-Aldrich

3-羟基苄肼 二盐酸盐

≥98.0% (HPLC)

别名:

α-肼基--甲酚 二盐酸盐, 3-(肼基甲基)苯酚 二盐酸盐, NSD-1015

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关于此项目

线性分子式:
HOC6H4CH2NHNH2 · 2HCl
CAS Number:
分子量:
211.09
Beilstein:
9282965
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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质量水平

方案

≥98.0% (HPLC)

表单

solid

mp

137-140 °C
138-140 °C (lit.)

溶解性

H2O: 50 mg/mL, slightly hazy, faintly yellow

SMILES字符串

Cl[H].Cl[H].NNCc1cccc(O)c1

InChI

1S/C7H10N2O.2ClH/c8-9-5-6-2-1-3-7(10)4-6;;/h1-4,9-10H,5,8H2;2*1H

InChI key

ONOJPUDFIOEGCX-UHFFFAOYSA-N

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生化/生理作用

L-芳香族氨基酸脱羧酶抑制剂;穿过血脑屏障。
L-芳香族氨基酸脱羧酶抑制剂;穿过血脑屏障。还可通过形成该辅因子的3-羟基苄基腙,还抑制GABA转氨酶以及其他需要磷酸吡哆醛的酶。

象形图

CorrosionExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Adrian M Russo et al.
Behavioural brain research, 359, 918-926 (2018-06-24)
Autism spectrum disorder (ASD) is a heterogeneous and highly heritable condition with multiple aetiologies. Although the biological mechanisms underlying ASD are not fully understood, evidence suggests that dysregulation of serotonergic systems play an important role in ASD psychopathology. Preclinical models
Anees A Banday et al.
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The role of dopamine D1-like receptors (DR) in the regulation of renal Na+ transporters, natriuresis, and blood pressure is well established. However, the involvement of the angiotensin 1-7 (ANG 1-7)-Mas receptor in the regulation of Na+ balance and blood pressure

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血清素(5-羟色胺)主要存在于三种主要细胞类型中:i)中杻神经系统(CNS)和肠肌间神经丛中的血清素能神经元,ii)胃肠道粘膜中的肠嗜铬细胞,和iii)血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶(MAO)进行,它以两种分子亚型存在,分别称为MAO-A和MAO-B。

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