Merck
CN

54880

Sigma-Aldrich

3-羟基苄肼 二盐酸盐

≥98.0% (HPLC)

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别名:
α-肼基--甲酚 二盐酸盐, 3-(肼基甲基)苯酚 二盐酸盐, NSD-1015
线性分子式:
HOC6H4CH2NHNH2 · 2HCl
CAS号:
分子量:
211.09
Beilstein:
9282965
EC 号:
MDL编号:
PubChem化学物质编号:

检测方案

≥98.0% (HPLC)

形式

solid

mp

137-140 °C
138-140 °C (lit.)

溶解性

H2O: 50 mg/mL, slightly hazy, faintly yellow

SMILES string

Cl[H].Cl[H].NNCc1cccc(O)c1

InChI

1S/C7H10N2O.2ClH/c8-9-5-6-2-1-3-7(10)4-6;;/h1-4,9-10H,5,8H2;2*1H

InChI key

ONOJPUDFIOEGCX-UHFFFAOYSA-N

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生化/生理作用

L-芳香族氨基酸脱羧酶抑制剂;穿过血脑屏障。还可通过形成该辅因子的3-羟基苄基腙,还抑制GABA转氨酶以及其他需要磷酸吡哆醛的酶。

象形图

CorrosionExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Serotonin (5-hydroxytryptamine) is principally found stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaffin cells in the mucosa of the gastrointestinal tract, and iii) in blood platelets. Metabolism of serotonin is carried out primarily by the outer mitochondrial membrane enzyme monoamine oxidase (MAO), which occurs as two molecular subtypes called MAO-A and MAO-B.

血清素(5-羟色胺)主要存在于三种主要细胞类型中:i)中杻神经系统(CNS)和肠肌间神经丛中的血清素能神经元,ii)胃肠道粘膜中的肠嗜铬细胞,和iii)血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶(MAO)进行,它以两种分子亚型存在,分别称为MAO-A和MAO-B。

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