56690
金丝桃素 来源于贯叶连翘
~95% (HPLC)
别名:
4,5,7,4′,5′,7′-六羟基-2,2′-二甲基萘并二蒽酮, Cyclo werrol, 金丝桃红
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经验公式（希尔记法）:
C30H16O8
化学文摘社编号:
分子量:
504.44
NACRES:
NA.77
PubChem Substance ID:
EC Number:
208-941-0
Beilstein/REAXYS Number:
1917913
MDL number:
UNSPSC Code:
51101500
产品名称
金丝桃素 来源于贯叶连翘, ~95% (HPLC)
InChI key
BTXNYTINYBABQR-UHFFFAOYSA-N
InChI
1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
SMILES string
Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c56
assay
~95% (HPLC)
solubility
1 M NaOH: 10 mg/mL, turbid, dark green
Quality Level
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Application
来自 贯叶连翘中的金丝桃素 已被用于：
- 在肉汤大量稀释测试和对细菌菌株的抗菌试验
- 作为人恶性黑素瘤细胞放射定位研究的培养基补充剂
- 作为孕烷 X 受体 (PXR) 的配体和作为原代人肝细胞培养的脱脂培养基补充剂
Biochem/physiol Actions
圣约翰麦芽汁中的蒽醌衍生物对革兰阳性和阴性菌均有效。
金丝桃素是蛋白激酶 C (PKC)、端粒酶、细胞色素 P450 和逆转录酶的强效抑制剂。它在光动力疗法 (PDT) 和肿瘤细胞光动力诊断 (PDD) 中具有光敏功能。
General description
疏水金丝桃素是一种天然存在于 贯叶连翘中的红色色素 ，可在 600 nm 处测量其荧光。其位于细胞内膜，包括核膜、线粒体膜、高尔基体、溶酶体和内质网。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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