56720
鹅膏氨酸 一水合物 来源于鹅膏 属
≥99.0% (TLC)
别名:
α-(3-羟基-5-异噁唑基)甘氨酸, α-氨基-3-羟基-5-异噁唑乙酸, 鹅膏蕈氨酸
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关于此项目
经验公式（希尔记法）:
C5H6N2O4 · H2O
化学文摘社编号:
分子量:
176.13
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1075440
MDL number:
assay
≥99.0% (TLC)
mp
148-151 °C
solubility
1 M NH4OH: 50 mg/mL, clear, colorless to yellow
SMILES string
O.NC(C(O)=O)C1=CC(=O)NO1
InChI
1S/C5H6N2O4.H2O/c6-4(5(9)10)2-1-3(8)7-11-2;/h1,4H,6H2,(H,7,8)(H,9,10);1H2
InChI key
QVKQQLYSTODTJN-UHFFFAOYSA-N
Biochem/physiol Actions
Ibotenic acid, a 3-isoxazolol amino acid, is an AMPA subtype glutamate receptor agonist involved in signal activation and blockade. Ibotenic acid from mushrooms such as Amanita muscaria and pantherina is an inducer of the “pantherina” central nervous system poisoning syndrome.
Ibotenic acid, a mushroom chemical neurotoxin, is used alone and together with factors such as β-amyloid(25-35) to induce neurotoxic lesions in the brain.
Other Notes
Review; Studies on the glutamate receptor
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cristina Miguelez et al.
PloS one, 6(9), e24679-e24679 (2011-09-21)
Despite being the most effective treatment for Parkinson's disease, L-DOPA causes a development of dyskinetic movements in the majority of treated patients. L-DOPA-induced dyskinesia is attributed to a dysregulated dopamine transmission within the basal ganglia, but serotonergic and noradrenergic systems
Götz Lütjens et al.
Neuroscience letters, 508(1), 27-30 (2011-12-20)
Lesions of the rat entopeduncular nucleus (EPN), the equivalent to the human globus pallidus internus (GPi), have been shown to improve deficient prepulse inhibition (PPI) induced by the dopamine agonist apomorphine. We here tested the effect of EPN lesions on
A T Malouf et al.
The Journal of biological chemistry, 259(20), 12763-12768 (1984-10-25)
Glutamate is thought to be a major excitatory neurotransmitter in the vertebrate brain. In the preceding paper (Malouf, A. T., Schnaar, R. L., and Coyle, J. T. (1984) J. Biol. Chem. 259, 12756-12762), we demonstrated specific binding of [3H]glutamate to