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Product Name
(±)-α-硫辛酸, ≥98.0%
质量水平
方案
≥98.0% (HPLC)
≥98.0%
表单
solid
灼烧残渣
≤0.1%
缺失
≤0.2% loss on drying
沸点
>286 °C/1.013 hPa
mp
60-62 °C
溶解性
water: 0.87 g/L at 22 °C
密度
1.4 g/cm3 at 23 °C
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此商品 | T5625 | 437692 | 843789 |
|---|---|---|---|
| assay ≥98.0% (HPLC) | assay ≥99% (titration) | assay ≥99% (by assay) | assay ≥99.0% (acidimetric) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| form solid | form powder | form solid | form solid |
| storage temp. 2-8°C | storage temp. - | storage temp. 10-30°C | storage temp. 2-30°C |
| mp 60-62 °C | mp - | mp - | mp 59-62 °C |
| ign. residue ≤0.1% | ign. residue - | ign. residue - | ign. residue - |
一般描述
生化/生理作用
(±)-α-硫辛酸可直接清除自由基[4]，并能使升高的氧化应激水平下降。[5]此外它还具有助氧化剂活性。[4]αα-硫辛酸可在线粒体α酮酸脱氢酶复合体中发挥重要的辅基作用。[6]它可用作糖尿病远端对称性多发性神经病变的潜力治疗药物。[5]α-硫辛酸还用于治疗能量代谢损伤和氧化还原失衡疾病。[6]
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶）活性所需的抗氧化剂和辅酶。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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