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68224

N-十二烷酰-L-高丝氨酸内酯

Name: <I>N</I>-十二烷酰-<SC>L</SC>-高丝氨酸内酯
Brand: SIGMA

≥96% (HPLC), suitable for mass spectrometry (MS)

别名:

, , C12-HSL

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₉NO₃

化学文摘社编号:

137173-46-7

分子量:

283.41

NACRES:

NA.28

PubChem Substance ID:

329760775

UNSPSC Code:

12352211

MDL number:

MFCD11976890

Beilstein/REAXYS Number:

9281984

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属性

产品名称

N-十二烷酰-L-高丝氨酸内酯, ≥96% (HPLC)

Quality Level

100

assay

≥96% (HPLC)

form

powder or crystals

optical activity

[α]/D -25±5°, c = 0.2 in methanol

technique(s)

mass spectrometry (MS): suitable

color

white to off-white

suitability

conforms to structure for Proton NMR spectrum

storage temp.

−20°C

SMILES string

O=C1OCC[C@@H]1NC(CCCCCCCCCCC)=O

InChI

1S/C16H29NO3/c1-2-3-4-5-6-7-8-9-10-11-15(18)17-14-12-13-20-16(14)19/h14H,2-13H2,1H3,(H,17,18)/t14-/m0/s1

InChI key

WILLZMOKUUPJSL-AWEZNQCLSA-N

说明

Biochem/physiol Actions

N -十二酰基- L -高丝氨酸内酯是 N -酰基-高丝氨酸内酯家族的成员。 N -酰基高丝氨酸内酯（AHL）调控革兰阴性菌如 埃希杆菌 和 沙门菌 的基因表达，参与群体感应、细菌间的细胞间通讯；关于综述，请参见。细菌细胞间通讯已成为开发新型抗毒力药物的靶点，也是预防生物膜形成的研究热点。

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hcodes

H413

Hazard Classifications

Aquatic Chronic 4

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Identification of extracellular N-acylhomoserine lactone acylase from a Streptomyces sp. and its application to quorum quenching.

Sun-Yang Park et al.

Applied and environmental microbiology, 71(5), 2632-2641 (2005-05-05)

N-acylhomoserine lactones (AHLs) play an important role in regulating virulence factors in pathogenic bacteria. Recently, the enzymatic inactivation of AHLs, which can be used as antibacterial targets, has been identified in several soil bacteria. In this study, strain M664, identified

Detection, purification and characterisation of quorum-sensing signal molecules in plant-associated bacteria.

G Brelles-Mariño et al.

Journal of biotechnology, 91(2-3), 197-209 (2001-09-22)

Quorum sensing (also called autoinduction) is a term that describes an environmental sensing system that allows bacteria to monitor their own population density. Autoinduction relies upon the interaction of a small diffusible signal molecule (the autoinducer) with a transcriptional activator

Cytotoxicity of N-dodecanoyl-Lhomoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: a comparative study.

Sviridova, T. et al.

Central European Journal of Immunology, 38, 310-316 (2013)

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