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Merck
CN

68957

三 2-羰基乙基 磷盐酸盐 盐酸盐

BioUltra, suitable for electrophoresis, SDS-PAGE tested

别名:

TCEP.HCL, TCEP

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关于此项目

经验公式（希尔记法）:
C9H15O6P · HCl
化学文摘社编号:
51805-45-9
分子量:
286.65
UNSPSC Code:
12352128
NACRES:
NA.32
PubChem Substance ID:
329761275
MDL number:
MFCD00145469
Beilstein/REAXYS Number:
3724376

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产品名称

三 2-羰基乙基 磷盐酸盐 盐酸盐, BioUltra, suitable for electrophoresis, SDS-PAGE tested

InChI

1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H

InChI key

PBVAJRFEEOIAGW-UHFFFAOYSA-N

SMILES string

Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O

product line

BioUltra

assay

97.5-102.5%

form

powder

Quality Level

100

mol wt

286.65 g/mol

concentration

90-100 % (w/w) (Tris(2-carboxyethyl)phosphine hydrochloride)

technique(s)

electrophoresis: suitable

color

white

mp

175-177 °C

solubility

H2O: soluble

density

1.041 g/cm3 at 25 °C

suitability

SDS-PAGE tested

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Analysis Note

琼脂糖凝胶电泳符合要求

Application

TCEP.HCL 已被用于体内和体外的多种生物偶联应用，用于标记蛋白质和活生物，在温和的生理环境下具有良好的有效性。 TCEP.HCL适用于各种生物和合成应用。在酸性pH下，TCEP.HCL 可用于在水中不可逆地将有机二硫化物转化为硫醇。
水溶性试剂，用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。

Features and Benefits

该产品具有以下优点：

  • TCEP.HCL 降低活性氧水平。
  • 它提高谷胱甘肽和线粒体含量。
  • 它具有抗癌作用。

General description

三（2-羧乙基）膦盐酸（TCEP.HCl）是一种可用于含硫和含氮化合物的有用还原剂。TCEP.HCL及其产生的氧化物是水溶性的。 TCEP.HCL 具有富含电子的磷和氧原子，可以多种金属结合，如铑、铱、帕。在室温下它可在二恶烷中与铑和铱快速络合。 它可以还原各种肽和蛋白质中的二硫键。

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 1

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN6353
BCCM5857
BCCH3116
BCCG6486
BCCG0947

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Christopher R Schlieve et al.
Experimental eye research, 83(5), 1252-1259 (2006-08-29)
Retinal ganglion cells (RGCs) undergo apoptosis after axonal injury, in part regulated by an intracellular superoxide anion burst, for which the target(s) are unknown. Shifting the RGC redox state towards reduction and preventing sulfhydryl oxidation is neuroprotective in vitro and
Yiren Zeng et al.
Theriogenology, 162, 32-41 (2021-01-15)
Oocyte in vitro maturation (IVM) is a crucial process that determines subsequent in vitro embryo production. The present study investigated the effects of the antioxidant tris (2-carboxyethyl) phosphine hydrochloride (TCEP-HCL) on the in vitro maturation of porcine oocytes and in vitro developmental competence of
W H Fischer et al.
Rapid communications in mass spectrometry : RCM, 7(3), 225-228 (1993-03-01)
The suitability of the hydrochloride salt of tris(2-carboxyethyl)phosphine (TCEP) for in situ reduction with matrix-assisted laser desorption/ionization (MALDI) and liquid secondary ionization (LSI) mass spectrometry is evaluated. TCEP can be used to irreversibly reduce organic disulfides to thiols in water
Siming Chen et al.
Chemical communications (Cambridge, England), 49(12), 1226-1228 (2013-01-05)
A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be
Fang-Fang Cheng et al.
The Analyst, 139(16), 3860-3865 (2014-07-01)
The expression of microRNAs (miRNAs) is related to some cancer diseases. Recently, miRNAs have emerged as new candidate diagnostic and prognostic biomarkers for detecting a wide variety of cancers. Due to low levels, short sequences and high sequence homology among
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