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Merck
CN

70050

杨梅黄素

≥96.0% (HPLC)

别名:

3,3′,4′,5,5′,7-六羟基黄酮, 大麻双酮, 杨梅醇

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关于此项目

经验公式（希尔记法）:
C15H10O8
化学文摘社编号:
529-44-2
分子量:
318.24
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
57652239
EC Number:
208-463-2
Beilstein/REAXYS Number:
332331
MDL number:
MFCD00006827

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InChI key

IKMDFBPHZNJCSN-UHFFFAOYSA-N

InChI

1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H

SMILES string

Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3

assay

≥96.0% (HPLC)

form

powder

mp

≥300 °C, >300 °C (lit.)

solubility

ethanol: 10 mg/mL, clear to very faintly turbid, yellow to very deep greenish-yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Quality Level

200

Gene Information

human ... CYP1A2(1544)
mouse ... Hexa(15211)
rat ... Il4(287287), Tnf(24835)

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相关类别

General description

杨梅酮（MYR）一种天然的聚羟基黄烷醇化合物，最早从杨梅树中分离出来。

Application

杨梅酮可用于：
  • 研究其作为抗氧化剂对大鼠噪声性听力损失（NIHL）的预防作用
  • 用作黄酮类化合物测试波旁病毒（BRBV）的抗病毒活性和依赖于 RNA 的 RNA 聚合酶（RdRP）的抑制作用
  • 研究其对变形链球菌和白色念珠菌生物膜的治疗效果
  • 作为刺柏属植物中酚类化合物定量分析的参考标准

Biochem/physiol Actions

杨梅酮通过调节多信号通路发挥抗氧化和抗炎作用。此外，它还具有抗糖尿病和保肝作用。 杨梅酮可强烈抑制酵母 α-葡萄糖苷酶、 乙二醛酶 I 体外、和牛乳黄嘌呤氧化酶。此外，它还可促进 DNA 与拓扑异构酶 I 和 II 之间形成络合物，从而可能在癌症化疗中发挥价值。此外，杨梅酮还具有多种营养保健价值和疗效。

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN2343
BCCM6369
BCCK8931
BCCJ3198
BCCH3611

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Xiaominting Song et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 134, 111017-111017 (2020-12-19)
Myricetin(MYR) is a flavonoid compound widely found in many natural plants including bayberry. So far, MYR has been proven to have multiple biological functions and it is a natural compound with promising research and development prospects. This review comprehensively retrieved
M. Iio, et al.
Agricultural and Biological Chemistry, 48, 1559-1559 (1984)
Deepak Kumar Semwal et al.
Nutrients, 8(2), 90-90 (2016-02-20)
Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic
M. Iio et al.
Agricultural and Biological Chemistry, 49, 2173-2173 (1985)
Miguel López-Lázaro et al.
Mutation research, 696(1), 41-47 (2009-12-23)
DNA topoisomerases (topos) are the target of several drugs commonly used in cancer chemotherapy; these drugs induce topo-DNA complexes with either topo I or topo II that eventually trigger cell death. The inhibition of these enzymes induces DNA alterations that
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商品

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

实验方案

HPLC Analysis of Flavonoids on Ascentis® RP-Amide

Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide

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